ArticleNature materials2020
A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials.
Article in Nature materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 95 citations in OpenAlex.
- Hybridization chain reaction-based DNA nanoframeworks for biosensing and therapeutic applications.Nature protocols · 2026Review
- Supramolecular Interactions Modulate RNA:DNA Folding Observed via Nanopore Sensing.Angewandte Chemie (International ed. in English) · 2025Article
- Supramolecular macrocyclic artificial ion channels for biomedical applications.Fundamental research · 2025Review
- Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids.Angewandte Chemie (International ed. in English) · 2025Article
- Crystalline Assemblies of DNA Nanostructures and Their Functional Properties.Angewandte Chemie (International ed. in English) · 2025Review
- Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly.Nature communications · 2024Article
- Cascade dynamic assembly/disassembly of DNA nanoframework enabling the controlled delivery of CRISPR-Cas9 system.Science advances · 2023Article
- The wending rhombus: Self-assembling 3D DNA crystals.Biophysical journal · 2022Review
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- A DNAzyme-augmented bioorthogonal catalysis system for synergistic cancer therapy.Chemical science · 2022Article
- Synthesis of Bifacial Peptide Nucleic Acids with Diketopiperazine Backbones.Synlett : accounts and rapid communications in synthetic organic chemistry · 2022Article
- Single-Molecule Mechanochemical Sensing.Accounts of chemical research · 2022Article
- Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems.Science advances · 2022Article
- Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout.Analytical chemistry · 2022Article
- Screening of Minimalist Noncanonical Sites in Duplex DNA and RNA Reveals Context and Motif-Selective Binding by Fluorogenic Base Probes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- DNA origami nano-mechanics.Chemical Society reviews · 2021Review
- A dissipative pathway for the structural evolution of DNA fibres.Nature chemistry · 2021Article
- Functionalizing DNA nanostructures with natural cationic amino acids.Bioactive materials · 2021Article
- Unnatural bases for recognition of noncoding nucleic acid interfaces.Biopolymers · 2021Review
- Ensemble Sensing Using Single-Molecule DNA Copolymers.Analytical chemistry · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
The diversity of DNA duplex structures is limited by a binary pair of hydrogen-bonded motifs. Here we show that poly(thymine) self-associates into antiparallel, right-handed duplexes in the presence of melamine, a small molecule that presents a triplicate set of the hydrogen-bonding face of adenine. X-ray crystallography shows that in the complex two poly(thymine) strands wrap around a helical column of melamine, which hydrogen bonds to thymine residues on two of its three faces. The mechanical strength of the thymine-melamine-thymine triplet surpasses that of adenine-thymine base pairs, which enables a sensitive detection of melamine at 3 pM. The poly(thymine)-melamine duplex is orthogonal to native DNA base pairing and can undergo strand displacement without the need for overhangs. Its incorporation into two-dimensional grids and hybrid DNA-small-molecule polymers highlights the poly(thymine)-melamine duplex as an additional tool for DNA nanotechnology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.