Evidence map›Paper›PMID 32661370›Full record

ArticleNature nanotechnology2020

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.

Yi Shen, Francesco Simone Ruggeri, Daniele Vigolo, Ayaka Kamada, Seema Qamar, Aviad Levin, Christiane Iserman, Simon Alberti, Peter St George-Hyslop, Tuomas P J Knowles

Open access · greenAbstract read
In one paragraph

Article in Nature nanotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 184 citations in OpenAlex.

  1. Review
  2. Review
  3. Cellular and systemic modifiers of alpha-synuclein proteostasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  4. Review
  5. Coacervates as bio-inspired intermediates for materials processing.Chemical communications (Cambridge, England) · 2026
    Review
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Yi ShenCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-0456-3850
Francesco Simone RuggeriCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-1232-1907
Daniele VigoloSchool of Chemical Engineering, University of Birmingham, Birmingham, United Kingdom.
Ayaka KamadaCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Seema QamarCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Aviad LevinCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Christiane IsermanMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Simon AlbertiMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Peter St George-HyslopCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0003-0796-7209
Tuomas P J KnowlesCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom. tpjk2@cam.ac.uk.ORCID http://orcid.org/0000-0002-7879-0140
University of Cambridge · GBMax Planck Institute of Molecular Cell Biology and Genetics · DEUniversity Health Network · CAUniversity of Birmingham · GB

Funding

CIHREuropean Research Council 337969Wellcome Trust 203249Wellcome Trust 203249/Z/16/Z
6 · The paper itself

Abstract

Membrane-less organelles resulting from liquid-liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling and embryogenesis

Indexed as

Phase TransitionAnimalsBiomechanical PhenomenaBombyxCell LineFibroinsPeptidesProtein AggregatesProteinsStress, MechanicalTensile StrengthThermodynamicsFibroinsPeptidesProtein AggregatesProteins

Identifiers

PMID32661370
PMCPMC7116851
OpenAlexW3041345504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.