ArticleNature immunology2020
The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- Nationality and body location alter human skin microbiome.Applied microbiology and biotechnology · 2021Pooled it
- Microbiome and Inflammatory Biomarkers Associated With Palatal Wound Healing.Journal of periodontal research · 2025Trial
- Review
- Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models.Materials today. Bio · 2026Article
- Bioactive-coated porous anastomotic staples enhance anastomotic healing.Bioactive materials · 2026Article
- Controlled release of berberine modulates the wound microbiome to accelerate wound healing.Asian journal of pharmaceutical sciences · 2026Article
- Dysbiosis in the Pathogenesis of Atopic Dermatitis.The Journal of dermatology · 2026Review
- Interaction between tick and host microbiotas: a four-step waltz.Parasites & vectors · 2026Review
- Dead but not gone: the interplay between the programmed cell death process and surrounding bacteria.Infection and immunity · 2026Review
- Advanced Glycation End-Products Contribute to Delayed Diabetic Corneal Epithelial Wound Healing via the TLR4 Signaling.Investigative ophthalmology & visual science · 2026Article
- Article
- Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation.Frontiers in immunology · 2026Review
- Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions.Frontiers in microbiology · 2026Review
- Germanium-embedded bioactive fabric reduces bacterial bioburden and modulates fibroblast and macrophage behaviorFrontiers in bioengineering and biotechnology · 2026Article
- Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics.Burns & trauma · 2026Review
- Deciphering the Interlinked CXCR4-Mediated Feedback Loop Among Signaling Pathways in Diabetic Wound Healing.Current diabetes reviews · 2026Review
- The Multifaceted Properties of Copper and Zinc in Skin Healing.Dermatology and therapy · 2026Article
- Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities.International journal of molecular sciences · 2025Review
- The Role of the Microbiome in the Resolution of Infection-Induced Inflammation.ACS infectious diseases · 2025Review
- Escape From X Chromosome Inactivation as a Driver of Plasmacytoid DC Heterogeneity in Health and Disease.Immunological reviews · 2025Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC (pDC). Commensal bacteria colonizing skin wounds trigger activation of neutrophils to express the chemokine CXCL10, which recruits pDC and acts as an antimicrobial protein to kill exposed microbiota, leading to the formation of CXCL10-bacterial DNA complexes. These complexes and not complexes with host-derived DNA activate pDC to produce type I IFNs, which accelerate wound closure by triggering skin inflammation and early T cell-independent wound repair responses, mediated by macrophages and fibroblasts that produce major growth factors required for healing. These findings identify a key function of commensal microbiota in driving a central innate wound healing response of the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.