ArticleScientific reports2020
Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.
- The prevalence and risk factors for phantom limb pain: a cross-sectional survey.BMC neurology · 2024Pooled it
- Neuropathic Mechanisms in Phantom Pain: A Review of Pain Pathways and Peripheral Localization.Current neurology and neuroscience reports · 2026Review
- Review
- Resting-State Theta and Alpha Oscillations in Amputation and Phantom Limb Pain: A Pre-Registered High-Density EEG Study.Brain topography · 2026Article
- Resting-State Electroencephalography Networks Underlying Individual Differences in the Effects of Virtual Reality Visual Feedback on Deafferentation Pain.Journal of pain research · 2026Article
- Sensory Sensitivity Over Time After Lower Limb Amputation and Its Association with Phantom Limb Pain.Journal of pain research · 2026Article
- Transient synaptic refinement and glial adaptations after whisker denervation in adult mice.Frontiers in cellular neuroscience · 2026Article
- Chronic phantom pain as a rare phenomenon after gender-affirming surgery: a systematic comparison study.Pain reports · 2025Review
- The Role of Pharmacogenomics in Optimizing Ketamine Therapy for Post-Amputation Pain.Reports (MDPI) · 2025Review
- Vibrotactile Stimulation in Lower Extremity Amputation Patients Using a Noninvasive Vibration Device: A Pilot Study.Plastic and reconstructive surgery. Global open · 2025Article
- Phantom Limb Pain Management.The Journal of hand surgery · 2025Review
- A Dissociation Between Primary Motor Cortex Reorganization and Correlation with Pain Intensity in Phantom Limb Pain: A Systematic Review of fMRI Studies.International journal of general medicine · 2025Review
- Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- [Clinical updates on phantom limb pain : German version].Schmerz (Berlin, Germany) · 2023Review
- Peripherally-induced Movement Disorders: An Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Review
- Complex pattern of facial remapping in somatosensory cortex following congenital but not acquired hand loss.eLife · 2022Article
- Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.Brain and behavior · 2022Review
- transcranial Direct Current Stimulation (tDCS) for the treatment and investigation of Phantom Limb Pain (PLP).Psychoradiology · 2022Review
- Hand Transplants, Daily Functioning, and the Human Capacity for Limb Regeneration.Frontiers in cell and developmental biology · 2022Article
- Clinical updates on phantom limb pain.Pain reportsArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Phantom limb pain (PLP) has been associated with reorganization in primary somatosensory cortex (S1) and preserved S1 function. Here we examined if methodological differences in the assessment of cortical representations might explain these findings. We used functional magnetic resonance imaging during a virtual reality movement task, analogous to the classical mirror box task, in twenty amputees with and without PLP and twenty matched healthy controls. We assessed the relationship between task-related activation maxima and PLP intensity in S1 and motor cortex (M1) in individually-defined or group-conjoint regions of interest (ROI) (overlap of task-related activation between the groups). We also measured cortical distances between both locations and correlated them with PLP intensity. Amputees compared to controls showed significantly increased activation in M1, S1 and S1M1 unrelated to PLP. Neural activity in M1 was positively related to PLP intensity in amputees with PLP when a group-conjoint ROI was chosen. The location of activation maxima differed between groups in S1 and M1. Cortical distance measures were unrelated to PLP. These findings suggest that sensory and motor maps differentially relate to PLP and that methodological differences might explain discrepant findings in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.