ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2021
Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Uncommon location, diagnostic challenge: A case series of acral low-grade fibromyxoid sarcoma.Virchows Archiv : an international journal of pathology · 2026Article
- Primary malignant aneurysmal bone cyst of the metatarsal with PAFAH1B1::USP6 fusion: expanding the clinicopathologic spectrum of malignant USP6 translocated neoplasms.Skeletal radiology · 2026Article
- Cutaneous soft tissue tumors in the 5th edition of the World Health Organization classification of skin tumors: key updates and new entities.Journal of pathology and translational medicine · 2026Article
- Histopathogenesis of bone- and soft-tissue tumor spectrum with USP6 gene rearrangement: multiple partners involved in the tissue repair process.Histology and histopathology · 2023Review
- Aneurysmal bone cyst: a review.Journal of pathology and translational medicine · 2023Review
- Pediatric dermatofibrosarcoma protuberans: A clinicopathologic and genetic analysis of 66 cases in the largest institution in Southwest China.Frontiers in oncology · 2023Article
- Article
- Fibroma of tendon sheath is defined by a USP6 gene fusion-morphologic and molecular reappraisal of the entity.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Intraarticular nodular fasciitis-detection of USP6 gene fusions in three cases by targeted RNA sequencing.Virchows Archiv : an international journal of pathology · 2021Article
- Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing.Virchows Archiv : an international journal of pathology · 2020Article
- An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma).In vivo (Athens, Greece)Review
- Fibroma of Tendon Sheath Revisited.In vivo (Athens, Greece)Review
- Ubiquitin-specific Peptidase 6 (Cancer genomics & proteomicsReview
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fibroma of tendon sheath (FTS) is an uncommon benign fibroblastic/myofibroblastic neoplasm that typically arises in the tenosynovial tissue of the distal extremities. Histologically, it is a well-circumscribed proliferation of spindle cells within collagenous stroma with peripheral slit-like vessels. Most examples are relatively hypocellular and more densely collagenous than nodular fasciitis; however, a cellular variant has been described, which has considerable morphologic overlap with nodular fasciitis and has been shown to harbor USP6 translocations in a subset of cases. The incidence of these rearrangements and the identity of the USP6 fusion partners have not been described in detail. In this study we evaluate 13 cases of cellular fibroma of tendon sheath by anchored multiplex PCR/next generation sequencing in order to detect potential gene fusions. Nucleic acids of adequate quality were obtained in 11 cases, demonstrating gene fusions in 7/11 (64%), all of which involve USP6 with a variety of partners, including PKM, RCC1, ASPN, COL1A1, COL3A1, and MYH9. Some unusual histomorphologic findings were present in a subset of cases including palisading growth pattern, epithelioid cells, and osteoclast-like multinucleated giant cells, particularly in the tumors with PKM and ASPN gene partners. Overall, the findings support a biologic relationship between cellular fibroma of tendon sheath and other lesions within the spectrum of USP6-rearranged neoplasms, particularly nodular fasciitis.
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