Evidence map›Paper›PMID 32661244›Full record

ReviewTranslational psychiatry2020

Genetics of structural and functional brain changes in autism spectrum disorder.

Sheema Hashem, Sabah Nisar, Ajaz A Bhat, Santosh Kumar Yadav, Muhammad Waqar Azeem, Puneet Bagga, Khalid Fakhro, Ravinder Reddy, Michael P Frenneaux, Mohammad Haris

Abstract readReview
In one paragraph

Review in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Review
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  13. Sensory and developmental phenotyping ofbioRxiv : the preprint server for biology · 2026
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  17. Screening of CGG Trinucleotide Repeats WithinJournal of the Korean Academy of Child and Adolescent Psychiatry · 2026
    Article
  18. Review
  19. Novel mouse line with D277N mutation in theFrontiers in cell and developmental biology · 2026
    Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheema Hashem *Functional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Sabah Nisar *Functional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Ajaz A BhatFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.ORCID http://orcid.org/0000-0003-3640-6275
Santosh Kumar YadavFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Muhammad Waqar AzeemDepartment of Psychiatry, Sidra Medicine, Doha, Qatar.
Puneet BaggaCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Khalid FakhroDepartment of Human Genetics, Sidra Medicine, Doha, Qatar.ORCID http://orcid.org/0000-0002-3150-1276
Ravinder ReddyCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Michael P FrenneauxAcademic Health System, Hamad Medical Corporation, Doha, Qatar.
Mohammad HarisFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar. mharis@sidra.org.ORCID http://orcid.org/0000-0002-4945-2935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease's neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.

Indexed as

Autism Spectrum DisorderBrainGenomicsHumansPolymorphism, Single Nucleotide

Identifiers

PMID32661244
PMCPMC7359361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.