Evidence map›Paper›PMID 32661198›Full record

ArticleThe Journal of biological chemistry2020

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.

Sandeep K Ravala, Jesse B Hopkins, Caroline B Plescia, Samantha R Allgood, Madison A Kane, Jennifer N Cash, Robert V Stahelin, John J G Tesmer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Structural and dynamic changes in P-Rex1 upon activation by PIPbioRxiv : the preprint server for biology · 2024
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sandeep K RavalaDepartments of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Jesse B HopkinsBiophysics Collaborative Access Team, Illinois Institute of Technology, Advanced Photon Source, Argonne National Laboratory, Lemont, Illinois, USA.
Caroline B PlesciaThe Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.
Samantha R AllgoodDepartments of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Madison A KaneCollege of Engineering, California State University, Long Beach, California, USA.
Jennifer N CashDepartment of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0277-7652
Robert V StahelinThe Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-5443-7863
John J G TesmerDepartments of Biological Sciences, Purdue University, West Lafayette, Indiana, USA jtesmer@purdue.edu.ORCID 0000-0003-1125-3727
Purdue University West Lafayette · USArgonne National Laboratory · USCalifornia State University, Long Beach · USUniversity of Michigan · US

Funding

Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1M
LIPID-PROTEIN INTERACTIONS IN VIRAL ASSEMBLY AND VIRUS LIKE PARTICLE FORMATIONR01AI081077 · NIAID · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL · 2009 to 2019
$3.5M
Structure and Function of the LPLA2/LCAT Acyltransferase FamilyR01HL122416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TESMER, JOHN · 2015 to 2018
$1.9M
GPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9M
Drug Discovery in Infectious Disease TrainingT32AI148103 · NIAID · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL, YEO, YOON · 2020 to 2024
$949k
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
Development of a Real Time Cellular Tool to Monitor a Previously Untraceable LipidR21GM131352 · NIGMS · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL · 2018 to 2019
$413k
NCI NIH HHS R01 CA221289NHLBI NIH HHS R01 HL071818NHLBI NIH HHS R01 HL122416NIAID NIH HHS R01 AI081077NIAID NIH HHS T32 AI148103NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R21 GM131352NIH HHS S10 OD018090
6 · The paper itself

Abstract

Phosphatidylinositol (3,4,5)-trisphosphate (PIP

Indexed as

Cell MembraneGuanine Nucleotide Exchange FactorsCyclic AMP-Dependent Protein KinasesHumansPhosphorylationProtein DomainsCyclic AMP-Dependent Protein KinasesGuanine Nucleotide Exchange FactorsPREX1 protein, humanallosteric regulationand pleckstrin (DEP) domainbinding proteincell signalingcrystallographydishevelledEgl-10enzyme inactivationguanine nucleotide exchange factorguanine nucleotide exchange factor (GEF)lipid-protein interactionlipid signalingoncogenephosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (P-Rex1)protein kinase A (PKA)protein-lipid interactionprotein phosphorylationSAXS (small-angle X-ray scattering)

Identifiers

PMID32661198
PMCPMC7476721
OpenAlexW3043687209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.