Evidence map›Paper›PMID 32661197›Full record

ReviewThe Journal of biological chemistry2020

The molecular virology of coronaviruses.

Ella Hartenian, Divya Nandakumar, Azra Lari, Michael Ly, Jessica M Tucker, Britt A Glaunsinger

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 310 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
310citing papers in PubMed, 4 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

310 citing papers in PubMed, 4 syntheses or guidelines pooled it, 555 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. JAK inhibitors and COVID-19.Journal for immunotherapy of cancer · 2022
    Pooled it
  5. Article
  6. Review
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  8. Article
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  10. Review
  11. Article
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  17. Article
  18. Cell entry mechanisms of porcine enteric coronaviruses.The Journal of biological chemistry · 2026
    Review
  19. Article
  20. Review

250 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ella HartenianDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Divya NandakumarDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Azra LariDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Michael LyDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Jessica M TuckerDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Britt A GlaunsingerDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA; Department of Plant and Microbial Biology, University of California, Berkeley, California, USA; Howard Hughes Medical Institute, University of California, Berkeley, California, USA. Electronic address: glaunsinger@berkeley.edu.
University of California, Berkeley · USHoward Hughes Medical Institute · US

Funding

Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated HerpesvirusR01CA136367 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Britt A Glaunsinger · 2010 to 2026
$5.8M
NCI NIH HHS R01 CA136367
6 · The paper itself

Abstract

Few human pathogens have been the focus of as much concentrated worldwide attention as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its emergence into the human population and ensuing pandemic came on the heels of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collectively have reshaped our view of a virus family previously associated primarily with the common cold. It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. Here, we present the molecular virology of coronavirus infection, including its entry into cells, its remarkably sophisticated gene expression and replication mechanisms, its extensive remodeling of the intracellular environment, and its multifaceted immune evasion strategies. We highlight aspects of the viral life cycle that may be amenable to antiviral targeting as well as key features of its biology that await discovery.

Indexed as

Gene Expression Regulation, ViralVirus Physiological PhenomenaAnimalsAntigens, ViralCoronavirusCoronavirus InfectionsHost-Pathogen InteractionsHumansAntigens, Viralcellular immune responsecoronavirusendoplasmic reticulumendoplasmic reticulum (ER)innate immunitypathogenesisplus-stranded RNA virusRNA polymeraseSARS-CoV-2viral replicationvirologyvirusvirus entry

Identifiers

PMID32661197
PMCPMC7489918
OpenAlexW3042943159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.