Evidence map›Paper›PMID 32661194›Full record

ArticleThe Journal of biological chemistry2020

The role of the I

Hugh I Smith, Nicolas Guthertz, Emma E Cawood, Roberto Maya-Martinez, Alexander L Breeze, Sheena E Radford

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Disease-relevant βNature communications · 2023
    Article
  4. Supersaturation-Dependent Formation of Amyloid Fibrils.Molecules (Basel, Switzerland) · 2022
    Review
  5. The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Investigation of D76N βJournal of the American Society for Mass Spectrometry · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hugh I SmithAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Nicolas GuthertzAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.ORCID 0000-0001-7247-1176
Emma E CawoodAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-2707-8022
Roberto Maya-MartinezAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Alexander L BreezeAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Sheena E RadfordAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom s.e.radford@leeds.ac.uk.ORCID 0000-0002-3079-8039
University of Leeds · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M012573/1Wellcome Trust 094232Wellcome Trust 105222/Z/14/ZWellcome Trust 109154Wellcome Trust 109984204936Wellcome Trust 204963Wellcome Trust 204963/Z/16/Z
6 · The paper itself

Abstract

The D76N variant of human β

Indexed as

Molecular Dynamics SimulationProtein AggregatesAmino Acid SubstitutionAmyloidbeta 2-MicroglobulinCrystallography, X-RayHumansMutation, MissenseAmyloidbeta 2-MicroglobulinProtein AggregatesaggregationamyloidbiophysicsCDD76Nfolding intermediateNMRprotein aggregationprotein foldingreal-time foldingβ2-microglobulin

Identifiers

PMID32661194
PMCPMC7458819
OpenAlexW3043479456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.