Evidence map›Paper›PMID 32661180›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Disease Risk-Associated Genetic Variants in

Matija Hedl, Rui Sun, Clara Abraham

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matija HedlDepartment of Internal Medicine, Yale University, New Haven, CT 06520.
Rui SunDepartment of Internal Medicine, Yale University, New Haven, CT 06520.ORCID 0000-0003-4054-1365
Clara AbrahamDepartment of Internal Medicine, Yale University, New Haven, CT 06520 clara.abraham@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Functional outcomes of inflammatory bowel disease associated variantsR01DK099097 · NIDDK · YALE UNIVERSITY · PI CLARA ABRAHAM · 2013 to 2026
$7.0M
Integrative Genomic Analyses of Macrophages in Crohns DiseaseR01DK106593 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHO, JUDY H. · 2016 to 2020
$3.8M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK099097NIDDK NIH HHS R01 DK106593
6 · The paper itself

Abstract

STAT proteins can regulate both pro- and anti-inflammatory cytokine signaling. Therefore, identifying consequences of modulating expression of a given STAT is ultimately critical for determining its potential as a therapeutic target and for defining the mechanisms through which immune-mediated disease variants in

Indexed as

AllelesCell LineCytokinesGene ExpressionGenetic Predisposition to DiseaseGenetic VariationHumansInflammatory Bowel DiseasesInterferon-gammaInterleukin-12MacrophagesMyeloid CellsPhosphorylationReceptors, Pattern RecognitionSignal TransductionSTAT1 Transcription FactorCytokinesInterferon-gammaInterleukin-12Receptors, Pattern RecognitionSTAT1 protein, humanSTAT1 Transcription FactorSTAT4 protein, humanSTAT4 Transcription Factor

Identifiers

PMID32661180
PMCPMC7510936
OpenAlexW3042228509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.