Evidence map›Paper›PMID 32661121›Full record

ArticleInfection and immunity2020

Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies.

Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E Galán

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
    Review
  2. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xuyao JiaoDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA.
Sarah SmithKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom.
Gabrielle StackDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA.
Qi LiangKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom.
Allan BradleyKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom.
Paul KellamKymab Ltd., Babraham Research Campus, Cambridge, United Kingdom.
Jorge E GalánDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA jorge.galan@yale.edu.ORCID 0000-0002-6531-0355
Kymab (United Kingdom) · GBYale University · US

Funding

Typhoid Toxin and Salmonella Typhi pathogenesisR01AI114618 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2014 to 2023
$5.4M
Virulence factors of Salmonella TyphiR01AI079022 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2008 to 2012
$2.0M
Virulence factors of Salmonella TyphiR56AI079022 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2014 to 2014
$486k
NIAID NIH HHS R01 AI079022NIAID NIH HHS R01 AI114618NIAID NIH HHS R56 AI079022
6 · The paper itself

Abstract

Typhoid toxin is a virulence factor of

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsCell LineHumansMiceMice, TransgenicNeutralization TestsProtein BindingProtein TransportSalmonella typhiTyphoid FeverAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingBacterial ProteinsBacterial Toxinsbacterial pathogenesisbacterial toxinsinfectious diseasesmonoclonal antibodiesSalmonella ParatyphiSalmonella Typhitherapeuticstyphoid fever

Identifiers

PMID32661121
PMCPMC7504945
OpenAlexW3041084240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.