Evidence map›Paper›PMID 32661079›Full record

ArticleJournal of bacteriology2020

The (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile.

Astha Pokhrel, Asia Poudel, Kory B Castro, Michael J Celestine, Adenrele Oludiran, Alden J Rinehold, Anthony M Resek, Mariam A Mhanna, Erin B Purcell

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Analysis of essential genes inJournal of bacteriology · 2025
    Article
  4. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Astha PokhrelDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Asia PoudelDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Kory B CastroDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Michael J CelestineDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Adenrele OludiranDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Alden J RineholdDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Anthony M ResekDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Mariam A MhannaDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA.
Erin B PurcellDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, USA epurcell@odu.edu.ORCID 0000-0002-8736-0433
Old Dominion University · US

Funding

The Role of the Stringent Response in Clostridium difficile Survival and VirulenceK22AI118929 · NIAID · OLD DOMINION UNIVERSITY · PI PURCELL, ERIN BRIDGET · 2016 to 2017
$270k
NIAID NIH HHS K22 AI118929
6 · The paper itself

Abstract

The human pathogen

Indexed as

Amino Acid SequenceAnti-Bacterial AgentsBacterial ProteinsClostridioides difficileClostridium InfectionsDrug Resistance, BacterialGene Expression Regulation, BacterialGuanosine PentaphosphateGuanosine TriphosphateLigasesMicrobial Sensitivity TestsSequence AlignmentStress, PhysiologicalAnti-Bacterial AgentsBacterial ProteinsGuanosine PentaphosphateGuanosine TriphosphateLigasesalarmoneantibiotic tolerancebacterial metabolismClostridioides difficileguanosine tetra- and pentaphosphate(p)ppGppstress responsestringent response

Identifiers

PMID32661079
PMCPMC7484180
OpenAlexW3043179050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.