Evidence map›Paper›PMID 32661075›Full record

ArticleJournal of bacteriology2020

Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway.

Neetu Neetu, Madhusudhanarao Katiki, Aditya Dev, Stuti Gaur, Shailly Tomar, Pravindra Kumar

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Integrated Evaluation ofInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Neetu NeetuDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Madhusudhanarao KatikiDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Aditya DevDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Stuti GaurDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Shailly TomarDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Pravindra KumarDepartment of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India pravindra.kumar@bt.iitr.ac.in.ORCID 0000-0003-2128-7736
Indian Institute of Technology Roorkee · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chlorogenic acid (CGA) is a phenolic compound with well-known antibacterial properties against pathogens. In this study, structural and biochemical characterization was used to show the inhibitory role of CGA against the enzyme of the shikimate pathway, a well-characterized drug target in several pathogens. Here, we report the crystal structures of dehydroquinate synthase (DHQS), the second enzyme of the shikimate pathway, from

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBinding SitesCatalytic DomainChlorogenic AcidKineticsPhosphorus-Oxygen LyasesProtein BindingProvidenciaShikimic Acid3-dehydroquinate synthetaseAnti-Bacterial AgentsBacterial ProteinsChlorogenic AcidPhosphorus-Oxygen LyasesShikimic Acidchlorogenic aciddehydroquinate synthasedrug discoveryenzyme structureisothermal titration calorimetryprotein crystallizationshikimate pathwaysurface plasmon resonanceX-ray crystallography

Identifiers

PMID32661075
PMCPMC7925078
OpenAlexW3040738845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.