Evidence map›Paper›PMID 32661066›Full record

ArticleeNeuro

Orbitofrontal Cortex Encodes Preference for Alcohol.

John S Hernandez, David E Moorman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John S HernandezNeuroscience and Behavior Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003.
David E MoormanNeuroscience and Behavior Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003 moorman@umass.edu.
University of Massachusetts Amherst · US

Funding

Ethanol Dependence &Stress Effects on Ethanol DrinkingU01AA014095 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWARD C. BECKER · 2003 to 2026
$9.0M
4/8: INIA Stress and Chronic Alcohol Interactions: Impact of stress mediated locus coeruleus dysregulation on cognitive control and excessive drinkingU01AA025481 · NIAAA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI DAVID E MOORMAN, Elena Vazey · 2017 to 2026
$4.2M
University of Massachusetts IMSDR25GM099649 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BHATIA, SURITA R., PETERSEN, SANDRA L · 2012 to 2016
$2.4M
Identification and manipulation of orexin/hypocretin neuron populations in addictionR21DA041674 · NIDA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MOORMAN, DAVID E · 2016 to 2017
$439k
Orbitofrontal coding of alcohol preference and compulsive drinkingR21AA024571 · NIAAA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MOORMAN, DAVID E · 2016 to 2017
$419k
NIAAA NIH HHS R21 AA024571NIAAA NIH HHS U01 AA025481NIDA NIH HHS R21 DA041674NIGMS NIH HHS R25 GM099649
6 · The paper itself

Abstract

Orbitofrontal cortex (OFC) plays a key role in representation and regulation of reward value, preference, and seeking. OFC function is disrupted in drug use and dependence, but its specific role in alcohol use disorders has not been thoroughly studied. In alcohol-dependent humans OFC activity is increased by alcohol cue presentation. Ethanol (EtOH) also alters OFC neuron excitability

Indexed as

AlcoholismAlcohol DrinkingAnimalsConditioning, OperantEthanolMalePrefrontal CortexRatsRats, Long-EvansSelf AdministrationEthanolalcohol use disorderdependenceelectrophysiologyinstrumentalorbital cortexprefrontal cortex

Identifiers

PMID32661066
PMCPMC7365858
OpenAlexW3040753794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.