ArticleAntimicrobial agents and chemotherapy2020
Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.
Open access · greenAbstract read
In one paragraph
Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Review
- The inoculum effect of methicillin-susceptibleMicrobiology spectrum · 2026Article
- Cefazolin Inoculum Effect and Cefazolin Microbiological Treatment Failure in Serious Methicillin-Susceptible Staphylococcus aureus Infections: A Multicenter Retrospective Cohort Study.The Journal of infectious diseases · 2026Article
- The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies.Infectious diseases and therapy · 2026Review
- A biphasic metabolism-β-lactamase production landscape governs the inoculum effect in β-lactamase-expressingbioRxiv : the preprint server for biology · 2025Article
- Validation of a modified rapid test to detect the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus from bloodstream infections in hospitals from North and Latin America.The Journal of antimicrobial chemotherapy · 2025Article
- Prevalence of the cefazolin inoculum effect (CzIE) in nasal colonizing methicillin-susceptibleAntimicrobial agents and chemotherapy · 2024Article
- Penicillin susceptibility amongMicrobiology spectrum · 2024Article
- Prevalence of the Cefazolin Inoculum Effect (CzIE) in Nasal Colonizing Methicillin-SusceptiblemedRxiv : the preprint server for health sciences · 2024Article
- Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review.JAC-antimicrobial resistance · 2024Review
- Cefadroxil and cephalexin pharmacokinetics and pharmacodynamics in children with musculoskeletal infections.Antimicrobial agents and chemotherapy · 2024Article
- Epidemiology and impact of methicillin-sensitiveAntimicrobial agents and chemotherapy · 2023Article
- Invasive Community-Onset Gram-Positive Infections From July 2018 Through December 2022 at 2 Children's Hospitals.Open forum infectious diseases · 2023Article
- Disc Test for Detecting Staphylococcus aureus Strains Producing Type A and Type C β-Lactamases.Microbiology spectrum · 2023Article
- Microbubble cavitation restores Staphylococcus aureus antibiotic susceptibility in vitro and in a septic arthritis model.Communications biology · 2023Article
- Going Back in Time: Increasing Penicillin Susceptibility among Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.Antimicrobial agents and chemotherapy · 2023Article
- Reduced Ceftaroline Susceptibility among Invasive MRSA Infections in Children: a Clinical and Genomic Investigation.Antimicrobial agents and chemotherapy · 2022Article
- Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections.Microbiology spectrum · 2022Article
- Prevalence and Characterization of the Cefazolin Inoculum Effect in North American Methicillin-Susceptible Staphylococcus aureus Isolates.Journal of clinical microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
J Chase McNeilDepartment of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA jm140109@bcm.tmc.edu skaplan@bcm.edu.ORCID 0000-0002-0232-7491
Lauren M SommerDepartment of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Mary BoyleDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Patrick HoganDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Jesus G VallejoDepartment of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Kristina G HulténDepartment of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Anthony R FloresDepartment of Pediatrics, Division of Infectious Diseases, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0002-6402-4269
Sheldon L KaplanDepartment of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA jm140109@bcm.tmc.edu skaplan@bcm.edu.
Stephanie FritzDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Baylor College of Medicine · USWashington University in St. Louis · USThe University of Texas Health Science Center at Houston · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MRole of Staphylococcus aureus alpha-hemolysin in diseaseR01AI097434 · NIAID · WASHINGTON UNIVERSITY · PI BUBECK WARDENBURG, JULIANE · 2012 to 2021
$4.0MIntegrating Personal and Household Environmental Hygiene Measures to Prevent Methicillin-Resistant Staphylococcus aureus InfectionR01HS024269 · AHRQ · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2015 to 2019
$2.5MEPIDEMIOLOGY AND ERADICATION OF MRSA IN HOUSEHOLDS WITH CHILDRENR01HS021736 · AHRQ · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2012 to 2016
$2.5MThe Impact of Healthcare Exposure on Colonization with Antiseptic Tolerant Staphylococci in ChildrenR01HS026896 · AHRQ · BAYLOR COLLEGE OF MEDICINE · PI MCNEIL, JONATHON CHASE · 2019 to 2023
$2.4MStaphylococcus aureus resistance to topical antimicrobial agents in childrenK23AI099159 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MCNEIL, JONATHON CHASE · 2013 to 2017
$821kTRANSMISSION DYNAMICS OF CA-MRSA AMONG HOUSEHOLD MEMBERS AND THE HOME ENVIRONMENTK23AI091690 · NIAID · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2011 to 2014
$506kAHRQ HHS R01 HS021736AHRQ HHS R01 HS024269AHRQ HHS R01 HS026896NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NIAID NIH HHS K23 AI091690NIAID NIH HHS K23 AI099159NIAID NIH HHS R01 AI097434
Abstract
Select methicillin-susceptible
Indexed as
CefazolinStaphylococcal InfectionsAnti-Bacterial AgentsChildHumansMethicillinMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsCefazolinMethicillincefazolin inoculum effectcephalosporinMSSAosteomyelitispediatric
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.