Evidence map›Paper›PMID 32660810›Full record

ReviewTrends in biochemical sciences2020

Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks.

Xin Zhou, Sohum Mehta, Jin Zhang

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Heme sensing and trafficking in fungi.Fungal biology reviews · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Fluorescent Biosensor for Measuring Ras Activity in Living Cells.Journal of the American Chemical Society · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin ZhouDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Sohum MehtaDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Jin ZhangDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA. Electronic address: jzhang32@health.ucsd.edu.

Funding

Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2M
Mechanisms of Compartmentalized cAMP SignalingR01DK073368 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2006 to 2026
$7.6M
Multiplex in vivo imaging of cell-specific and circuit-specific signaling pathways during synaptic plasticityR01MH111516 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L, ZHANG, JIN · 2016 to 2018
$1.8M
Signal Transduction by PI3K/Akt/mTOR PathwayR01GM111665 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, JIN · 2015 to 2018
$1.2M
NCI NIH HHS R35 CA197622NIDDK NIH HHS R01 DK073368NIGMS NIH HHS R01 GM111665NIMH NIH HHS R01 MH111516
6 · The paper itself

Abstract

Cell signaling networks are intricately regulated in time and space to determine the responses and fates of cells to different cues. Genetically encodable fluorescent and bioluminescent biosensors enable the direct visualization of these spatiotemporal signaling dynamics within the native biological context, and have therefore become powerful molecular tools whose unique benefits are being used to address challenging biological questions. We first review the basis of biosensor design and remark on recent technologies that are accelerating biosensor development. We then discuss a few of the latest advances in the development and application of genetically encodable fluorescent and bioluminescent biosensors that have led to scientific or technological breakthroughs.

Indexed as

LuminescenceSignal TransductionBiosensing Techniquesbioluminescencecompartmentalizationin vivo imaginglive-cell imagingspatiotemporal regulationsuper-resolution

Identifiers

PMID32660810
PMCPMC7502535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.