Evidence map›Paper›PMID 32660692›Full record

ArticleeLife2020

Stable task information from an unstable neural population.

Michael E Rule, Adrianna R Loback, Dhruva V Raman, Laura N Driscoll, Christopher D Harvey, Timothy O'Leary

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Article
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  6. Stiefel Manifold Dynamical Systems for Tracking Representational Drift.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Distributed and drifting signals for working memory load in human cortex.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Representational drift without synaptic plasticity.bioRxiv : the preprint server for biology · 2025
    Article
  19. Representational drift and learning-induced stabilization in the piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael E RuleDepartment of Engineering, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-4196-774X
Adrianna R LobackDepartment of Engineering, University of Cambridge, Cambridge, United Kingdom.
Dhruva V RamanDepartment of Engineering, University of Cambridge, Cambridge, United Kingdom.
Laura N DriscollDepartment of Electrical Engineering, Stanford University, Stanford, United States.
Christopher D HarveyDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Timothy O'LearyDepartment of Engineering, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1029-0158

Funding

Studying perceptual decision-making across cortex by combining population imaging, connectomics, and computational modelingR01NS108410 · NINDS · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D, LEE, WEI-CHUNG ALLEN · 2018 to 2022
$5.7M
Parietal Cortex Networks for Sensorimotor Processing During NavigationR01NS089521 · NINDS · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D · 2015 to 2024
$4.5M
New approaches to understand neuronal microcircuit dynamics for working memoryR01MH107620 · NIMH · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D · 2015 to 2019
$2.8M
H2020 European Research Council FLEXNEURO 716643Human Frontier Science Program RGY0069NIH HHS MH107620NIH HHS NS089521NIH HHS NS108410NIMH NIH HHS R01 MH107620NINDS NIH HHS R01 NS089521NINDS NIH HHS R01 NS108410
6 · The paper itself

Abstract

Over days and weeks, neural activity representing an animal's position and movement in sensorimotor cortex has been found to continually reconfigure or 'drift' during repeated trials of learned tasks, with no obvious change in behavior. This challenges classical theories, which assume stable engrams underlie stable behavior. However, it is not known whether this drift occurs systematically, allowing downstream circuits to extract consistent information. Analyzing long-term calcium imaging recordings from posterior parietal cortex in mice (

Indexed as

AnimalsLearningMemoryMiceMice, Inbred C57BLNeuronsParietal Lobecomputational biologycomputational neurosciencelearning and memorymouseneural codingneuroscienceplasticityspatial navigationsystems biologysystems modeling

Identifiers

PMID32660692
PMCPMC7392606

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.