Evidence map›Paper›PMID 32660564›Full record

Trial reportLipids in health and disease2020

Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial.

M Dreßler, D Fussbroich, L Böhler, E Herrmann, N Benker, M Tytyk, J Schulze, R Schubert, C Beermann, S Zielen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02410096 (Examination of Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation With Middle-chain and Polyunsaturated Fatty Acids in an Exercise-induced Asthma Provocation Model), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02410096 nacompletednot on this map

Examination of Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation With Middle-chain and Polyunsaturated Fatty Acids in an Exercise-induced Asthma Provocation Model

TypeinterventionalSponsorJohann Wolfgang Goethe University HospitalRan2015 to 2016Enrolled73ConditionsExercise-induced AsthmaArmsExercise challenge in a cold chamber, Methacholine challenge, Oil supplementation verum, Oil supplementation placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M DreßlerDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
D FussbroichDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
L BöhlerDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
E HerrmannInstitute of Biostatistics and Mathematical Modelling, Goethe-University, Frankfurt/Main, Germany.
N BenkerDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
M TytykDepartment of Food Technology, University of Applied Science, Fulda, Germany.
J SchulzeDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
R SchubertDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany.
C BeermannDepartment of Food Technology, University of Applied Science, Fulda, Germany.
S ZielenDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-University, Frankfurt/Main, Germany. Stefan.Zielen@kgu.de.ORCID http://orcid.org/0000-0003-1204-0627
Goethe University Frankfurt · DEFulda University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV

methodsIn this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. PRIMARY OUTCOME MEASURE: Decrease in FEV

resultsNinety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV

conclusionSupplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA.

trial registrationClinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.gov.

Indexed as

AdolescentAdultAsthma, Exercise-InducedChromatography, GasDouble-Blind MethodFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansMaleMiddle AgedNitric OxideYoung AdultFatty Acids, Omega-3Fatty Acids, Omega-6Nitric OxideDouble-blind placebo-controlled trialExercise challengeExercise-induced asthmaExhaled nitric oxideForced expiratory volume in 1 sLong-chain polyunsaturated fatty acids

Identifiers

PMID32660564
PMCPMC7359229
OpenAlexW3042865159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.