Evidence map›Paper›PMID 32660487›Full record

ArticleBMC veterinary research2020

Immunohistochemical detection of p53 and pp53 Ser

María José García-Iglesias, Jose Luis Cuevas-Higuera, Ana Bastida-Sáenz, María Gracia de Garnica-García, Laura Polledo, Paula Perero, Jorge González-Fernández, Beatriz Fernández-Martínez, Claudia Pérez-Martínez

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Veterinary world · 2025
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

María José García-IglesiasHistology and Pathological Anatomy Section, Department of Animal Health, Faculty of Veterinary Medicine, University of León, León, Spain.
Jose Luis Cuevas-HigueraHistology and Pathological Anatomy Section, Department of Animal Health, Faculty of Veterinary Medicine, University of León, León, Spain.
Ana Bastida-SáenzHistology and Pathological Anatomy Section, Department of Animal Health, Faculty of Veterinary Medicine, University of León, León, Spain.
María Gracia de Garnica-GarcíaMicrosVeterinaria, León, Spain.
Laura PolledoMicrosVeterinaria, León, Spain.
Paula PereroHistology and Pathological Anatomy Section, Department of Animal Health, Faculty of Veterinary Medicine, University of León, León, Spain.
Jorge González-FernándezMicrosVeterinaria, León, Spain.
Beatriz Fernández-MartínezMicrosVeterinaria, León, Spain.
Claudia Pérez-MartínezHistology and Pathological Anatomy Section, Department of Animal Health, Faculty of Veterinary Medicine, University of León, León, Spain. cperm@unileon.es.ORCID http://orcid.org/0000-0001-8060-6368
Universidad de León · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundp53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable than the wild-type p53. However, post-translational modifications of p53 in response to ultraviolet radiation are important mechanisms of wild-type p53 stabilization, leading to positive staining in the absence of mutation. The aims were: 1) to analyze the immunohistochemical expression of p53 and phospho-p53 Serine

resultsp53 and phospho-p53 Serine

conclusionsThe p53 and phospho-p53 Serine

Indexed as

AnimalsCell ProliferationDog DiseasesDogsFemaleHemangiomaHemangiosarcomaImmunohistochemistryKi-67 AntigenMaleSkin NeoplasmsTumor Suppressor Protein p53Tumor Suppressor ProteinsUltraviolet RaysKi-67 AntigenTumor Suppressor Protein p53Tumor Suppressor ProteinsCell proliferationDogHemangiomasHemangiosarcomasKi-67p53Phospho-p53 Serine392Skin

Identifiers

PMID32660487
PMCPMC7359283
OpenAlexW3040991438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.