Evidence map›Paper›PMID 32660457›Full record

SynthesisBMC pediatrics2020

Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis.

Amer Alsaied, Nazmul Islam, Lukman Thalib

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 13 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 13 syntheses or guidelines pooled it, 262 citations in OpenAlex.

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  9. Quality of life after necrotizing enterocolitis: an integrative review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024
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  14. Trial
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  16. Effect of Maternal Diet on Any Necrotizing Enterocolitis in Neonates: A Randomized Double-Blind Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022
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  20. Photoacoustic imaging of intestinal physiological biomarkers in infants and children.medRxiv : the preprint server for health sciences · 2026
    Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amer AlsaiedDepartment of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Nazmul IslamDepartment of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Lukman ThalibDepartment of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar. Lthalib@qu.edu.qa.ORCID 0000-0002-1211-6495
Qatar University · QAEquine Veterinary Medical Center · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNecrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).

methodsThe databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Incidence were pooled using Random Effect Models (REM), in the presence of substantial heterogeneity. Additional, bias adjusted Quality Effect Models (QEM) were used to get sensitivity estimates. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias.

resultsA systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The number of neonate included in these studies was 574,692. Of this 39,965 developed NEC. There were substantial heterogeneity between studies (I

conclusionSeven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted.

Indexed as

Enterocolitis, NecrotizingInfant, Premature, DiseasesHumansIncidenceInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightIncidenceMeta-analysisNecrotizing EnterocolitisSystematic review

Identifiers

PMID32660457
PMCPMC7359006
OpenAlexW3040924159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.