ReviewBMC ophthalmology2020
Ophthalmic manifestations of congenital protein C deficiency: a case report and mini review.
Review in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Prenatal Etiology Diagnosis of Rare Compound Heterozygous PROC Gene Variants in a Fetus With Ocular Ultrasonic Anomaly Using Whole Exome Sequencing.Molecular genetics & genomic medicine · 2026Article
- Severe Multisystem Thrombotic Phenotype Associated With Protein C Deficiency in A Young Woman: A Case Report.Clinical case reports · 2026Article
- Activated Protein C and the Retina: From Physiology to Therapeutic Potential.International journal of molecular sciences · 2026Review
- Neonatal Purpura Fulminans: An Unusual Cause of Leukocoria, Retinal Detachment, and Vitreous Hemorrhage in Neonates.Cureus · 2026Article
- Compound heterozygous congenital protein C deficiency: a challenging management with recurrent purpura fulminans treated with protein C concentrations.BMJ case reports · 2025Article
- [Analysis of two cases of hereditary protein C deficiency causing venous thrombosis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Successful Pregnancy Outcome in a Patient with Recurrent Miscarriage Due to PCOS Complicated by Hereditary Protein C Deficiency.International journal of women's health · 2025Article
- Lens-sparing vitrectomy for pediatric tractional retinal detachment in homozygous protein C deficiency.American journal of ophthalmology case reports · 2024Article
- Surgical treatment of traction retinal detachment associated with compound heterozygous congenital protein C deficiency.American journal of ophthalmology case reports · 2023Article
- Avascular Peripheral Retina in Infants.Turkish journal of ophthalmology · 2023Review
- 3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation.International journal of molecular sciences · 2022Article
- [Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Article
- Severe protein C deficiency in a newborn caused by a homozygous pathogenic variant in the PROC gene: a case report.BMC pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHomozygous protein C (PC) deficiency is a potentially fatal disease with ocular blinding presentation or sequela. CASE PRESENTATION: A 5 month-old boy was presented for evaluation of leukocoria. He had a history of frequent bruises and PC deficiency, treated with warfarin. His intraocular pressure was normal. In the left eye leukoma with anterior segment dysgenesis, shallow anterior chamber, and cataract were observed. Fundus was not visible. B-scan revealed a closed funnel retinal detachment. His right eye had a normal anterior segment and a thin retina with anomalous retinal vascular branching at equator and peripheral retina. A fibrovascular tuft on the optic nerve head with induced traction on superior arcade was visible. Total loss of a and b wave of both were appreciated in electroretinography (ERG). Fluorescein angiography (FA) showed very severe leakage at the junction of the vascularized and non-vascularized retina and optic nerve head. Favorable outcome was achieved with lasering of avascular retina in the right eye.
conclusionThe potential for protein C deficiency should be assessed in all infants with leukocoria, anterior segment dysgenesis, retinal detachment and retinal dysplasia. Early diagnosis could save the child's life and vision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.