ArticleBMC cancer2020
Fibroadenoma versus phyllodes tumor: a vexing problem revisited!
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Fine Needle Aspiration Cytology of Adenomyoepithelioma of the Breast: Cytologic Findings and Histologic Correlations.Diagnostic cytopathology · 2026Article
- Myxoid Fibroadenoma of the Breast With Radiologic-Pathologic Correlation: A Case Report.Cureus · 2026Article
- Diagnostic and management challenges in a partially infarcted borderline phyllodes tumor in an adolescent female: A case report and review of literature.World journal of clinical pediatrics · 2025Article
- A convenient model based on mammography and magnetic resonance imaging for preoperative differentiation of breast phyllodes tumors and fibroadenomas.Gland surgery · 2025Article
- Hierarchical diagnosis of breast phyllodes tumors enabled by deep learning of ultrasound images: a retrospective multi-center study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- From Fibroadenoma to Phyllodes Tumor: Case Analysis of Borderline and Giant Breast Tumors with Literature Review.Acta medica Lituanic · 2025Article
- Phyllodes Tumor, A Cytomorphologic Study of 17 Cases with Histologic Correlation.Iranian journal of pathology · 2025Article
- Article
- A Unique Case of a Massive Fungating Fibroadenoma of the Breast: Clinical and Pathological Insights.Cureus · 2024Article
- Rapid Onsite Evaluation for Specimen Adequacy and Triage of Breast Masses in a Low-Resource Setting.Archives of pathology & laboratory medicine · 2024Article
- Differentiation between Phyllodes Tumors and Fibroadenomas through Breast Ultrasound: Deep-Learning Model Outperforms Ultrasound Physicians.Sensors (Basel, Switzerland) · 2023Article
- Fibroepithelial Lesion Spectrum: A Case Report Documenting a Possible Transformation to a Malignant Phyllodes Tumor.Cureus · 2023Article
- Classic illustrations of benign and malignant phyllodes breast tumors in two patients.Radiology case reports · 2023Article
- Prevalence, Impact, and Diagnostic Challenges of Benign Breast Disease: A Narrative Review.International journal of women's health · 2023Review
- Native T1 mapping of the breast in MRI to differentiate fibroadenomas from benign phyllodes tumors: a preliminary study.Magma (New York, N.Y.) · 2022Article
- Fibroepithelial lesions: assessing the risk of malignant phyllodes tumors in the breast.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibroepithelial lesions of the breast include fibroadenoma (FA) and phyllodes tumor (PT). Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of distant metastasis. Our study was to determine the select cytologic features that can accurately distinguish FA from PT.
methodsA retrospective review was performed of patients who had histopathology follow up of FA or PT and on whom a pre-operative fine needle aspiration was performed. Cytologic criteria i.e. epithelial component, stromal component and background cellularity were assessed.
results46 FA and 24 PT were specimens were reviewed. Median age and tumor size for FA and PT were 23.0 and 39.0 years, and 2.0 and 5.0 cm, respectively. Univariate analysis and regression models based on generalized estimating equations revealed that large opened out, folded epithelial sheets, frayed and irregular stromal fragment contours, spindle stromal cell nuclei, spindle cell nuclei in the background and background cell atypia are significant cytological predictors of PT. The GEE regression model achieved 78.9% diagnostic accuracy (p < 0.001) in identifying PT based on cytological features. Median epithelial: stromal ratio was 3.4 and 2.6 for FA and PT, respectively.
conclusionPresence of large, opened out, folded epithelial sheets, frayed and irregular stromal contours with spindle nuclei, background spindle cells and atypia can help distinguish PT from FA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.