Evidence map›Paper›PMID 32660431›Full record

ArticleBMC gastroenterology2020

Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV.

Tongai Gibson Maponga, Richard H Glashoff, Hannali Vermeulen, Barbara Robertson, Sean Burmeister, Marc Bernon, Jones Omoshoro-Jones, Paul Ruff, Alfred I Neugut, Judith S Jacobson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Tongai Gibson MapongaDivision of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa. tongai@sun.ac.za.ORCID http://orcid.org/0000-0002-6876-3712
Richard H GlashoffDivision of Medical Microbiology & Immunology, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.
Hannali VermeulenDivision of Radiation Oncology, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.
Barbara RobertsonDivision of Radiation Oncology, University of Cape Town, Cape Town, South Africa.
Sean BurmeisterDepartment of Surgery, University of Cape Town, Cape Town, South Africa.
Marc BernonDepartment of Surgery, University of Cape Town, Cape Town, South Africa.
Jones Omoshoro-JonesDepartment of Surgery, University of Witwatersrand, Johannesburg, South Africa.
Paul RuffDivision of Medical Oncology, University of Witwatersrand, Johannesburg, South Africa.
Alfred I NeugutDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA.
Judith S JacobsonHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, USA.
Wolfgang PreiserDivision of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.
Monique I AnderssonDivision of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.
Stellenbosch University · ZAUniversity of Cape Town · ZAColumbia University · USNational Health Laboratory Service · ZAUniversity of the Witwatersrand · ZA

Funding

Columbia-South Africa Training Program for Research on HIV-associated MalignanciD43CA153715 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEUGUT, ALFRED I. · 2010 to 2013
$1.8M
Harry Crossley Foundation NANational Health Laboratory Services Research Trust (ZA) NANCI NIH HHS 1D43CA153715NCI NIH HHS D43 CA153715Poliomyelitis Research Foundation NA
6 · The paper itself

Abstract

backgroundPatients co-infected with hepatitis B virus (HBV) and the human immunodeficiency virus (HIV) are at risk of developing hepatocellular carcinoma (HCC). In sub-Saharan Africa, the overlap between high HIV and HBV prevalence may increase the incidence of HCC. This study investigated the impact of HBV/HIV co-infection on age at presentation and survival of HCC.

methodsEthical approval was obtained to recruit, following informed written consent, patients diagnosed with HCC at oncology units at four South African hospitals. Between December 2012 and August 2015, patients newly diagnosed with HCC were recruited and provided demographic and clinical data and blood specimens. Patients were tested for HBV, hepatitis C virus (HCV) and HIV. Survival data was available for a subset of patients.

resultsOf 107 HCC cases, 83 (78%) were male. Median age was 46 years (range 18 to 90 years), 68/106 (64%) were HBsAg-positive, and 22/100 (22%) were HIV infected. Among HBV surface antigen (HBsAg)-positive HCC cases, 18/66 (27%) were HIV-infected compared to 3/34 (9%) among those that were HBsAg-negative (p = 0.04). A greater proportion of HBV/HIV co-infected cases were female than HBV mono-infected (6/18, 33% vs 6/47, 13%; p = 0.005). In addition, HBV/HIV co-infected females presented at a younger mean age (36.8 years) than HBV mono-infected women (50.5 years) (p = 0.09). Median survival was 82 days among the HIV-infected HCC patients compared to 181 days among those without HIV (p = 0.15).

conclusionsHCC is an important complication in the HIV/HBV infected patient. HIV-positive patients presented with HCC at a younger age than HIV-negative patients, this effect appears to be greater in women. These data provide more evidence supporting the call to address. HCC as a cause of morbidity and mortality in the HBV/HIV co-infected patient population. (281 words).

Indexed as

Carcinoma, HepatocellularHepatitis BHIV InfectionsLiver NeoplasmsAdolescentAdultAgedAged, 80 and overFemaleHepatitis B Surface AntigensHepatitis B virusHumansMaleMiddle AgedSouth AfricaYoung AdultHepatitis B Surface AntigensAge at presentationHepatitis B infectionHepatocellular carcinomaHIV infectionNatural historySurvival

Identifiers

PMID32660431
PMCPMC7359588
OpenAlexW3043082103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.