ArticleBMC genomics2020
Adaptation of pine wood nematode Bursaphelenchus xylophilus to β-pinene stress.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- The pinewood nematode enhances population growth by exploiting host defensive terpenes via lysosomal signaling.Pest management science · 2026Article
- Genome-Wide Identification and Expression Analysis of mBiology · 2026Article
- Botanical Extracts for the Control of Plant-Parasitic Nematodes: Diversity, Modes of Action, Advanced Formulations, and Efficacy.Plants (Basel, Switzerland) · 2026Review
- Cloning, expression and characterisation of short-chain dehydrogenase/reductase SDR12 (A0A7I5E7J1) from a parasitic nematode Haemonchus contortus.Scientific reports · 2026Article
- Genome-wide characterization of theFrontiers in plant science · 2026Article
- IbPIF1 confers stem nematode resistance by regulating secondary metabolites in sweet potato.Plant biotechnology journal · 2025Article
- Analysis of the sulfate permease family inFrontiers in plant science · 2025Article
- Identification and Transcriptome Analysis ofInternational journal of molecular sciences · 2024Article
- Whole-Genome Sequences of 13 Chinese Indigenous Pinewood Nematodes,International journal of molecular sciences · 2024Article
- Alpha- and beta-pinene isomers act differently to control Rhipicephalus microplus (Acari: Ixodidae).Parasitology research · 2024Article
- Pine wilt disease: what do we know from proteomics?BMC plant biology · 2024Review
- Engineered pine endophyticFrontiers in microbiology · 2023Article
- Transcriptome analysis reveals the high ribosomal inhibitory action of 1,4-naphthoquinone onFrontiers in plant science · 2023Article
- Xenobiotic-Metabolizing Enzymes in Trematodes.Biomedicines · 2022Review
- Article
- Molecular variation among virulent and avirulent strains of the quarantine nematode Bursaphelenchus xylophilus.Molecular genetics and genomics : MGG · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundThe pine wood nematode (PWN; Bursaphelenchus xylophilus) is the most damaging biological pest in pine forest ecosystems in China. However, the pathogenic mechanism remains unclear. Tracheid cavitation induced by excess metabolism of volatile terpenes is a typical characteristic of pine trees infected by B. xylophilus. β-pinene, one of the main volatile terpenes, influences PWN colonization and reproduction, stimulating pathogenicity during the early stages of infection. To elucidate the response mechanism of PWN to β-pinene, pathogenesis, mortality, and reproduction rate were investigated under different concentrations of β-pinene using a transcriptomics approach.
resultsA low concentration of β-pinene (BL, C < 25.74 mg/ml) inhibited PWN reproduction, whereas a high concentration (BH, C > 128.7 mg/ml) promoted reproduction. Comparison of PWN expression profiles under low (BL, 21.66 mg/ml) and high (BH, 214.5 mg/ml) β-pinene concentrations at 48 h identified 659 and 418 differentially expressed genes (DEGs), respectively, compared with controls. Some key DEGs are potential regulators of β-pinene via detoxification metabolism (cytochrome P450, UDP-glucuronosyltransferases and short-chain dehydrogenases), ion channel/transporter activity (unc and ATP-binding cassette families), and nuclear receptor -related genes. Gene Ontology enrichment analysis of DEGs revealed metabolic processes as the most significant biological processes, and catalytic activity as the most significant molecular function for both BL and BH samples. Kyoto Encyclopedia of Genes and Genomes (KEGG) Orthology (KO) analysis showed that xenobiotics biodegradation and metabolism, carbohydrate metabolism, lipid metabolism, amino acid metabolism, metabolism of cofactors and vitamins, and transport and catabolism were the dominant terms in metabolism categories.
conclusionIn addition to detoxification via reduction/oxidation (redox) activity, PWN responds to β-pinene through amino acid metabolism, carbohydrate metabolism, and other pathways including growth regulation and epidermal protein changes to overcome β-pinene stress. This study lays a foundation for further exploring the pathogenic mechanism of PWN.
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