Evidence map›Paper›PMID 32660382›Full record

ReviewAnnual review of microbiology2020

Bacterial Quorum Sensing During Infection.

Sheyda Azimi, Alexander D Klementiev, Marvin Whiteley, Stephen P Diggle

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Characterization of a Novel Quorum QuencherPlants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. EngineeredBiochemistry · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Biophysical Constraints Dictate the Stability of Social Traits inbioRxiv : the preprint server for biology · 2026
    Article
  10. Novel Pyridine-Based Thiazolyl-Hydrazone as a Promising Attenuator ofInternational journal of molecular sciences · 2026
    Article
  11. Article
  12. Review
  13. Quorum sensing geneFrontiers in microbiology · 2026
    Article
  14. Virulence regulation in the fish pathogenFrontiers in cellular and infection microbiology · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sheyda AzimiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA; email: marvin.whiteley@biosci.gatech.edu, stephen.diggle@biosci.gatech.edu.
Alexander D KlementievSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA; email: marvin.whiteley@biosci.gatech.edu, stephen.diggle@biosci.gatech.edu.
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA; email: marvin.whiteley@biosci.gatech.edu, stephen.diggle@biosci.gatech.edu.
Stephen P DiggleSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA; email: marvin.whiteley@biosci.gatech.edu, stephen.diggle@biosci.gatech.edu.

Funding

Understanding in vivo antibiotic resistance in diverse Pseudomonas aeruginosa populationsR01AI153116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DIGGLE, STEPHEN PAUL · 2021 to 2025
$2.3M
Mechanisms of Pseudomonas aeruginosa virulence in polymicrobial wound infectionsR01GM116547 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2016 to 2019
$1.2M
Bacterial regulatory evolution during adaptation to chronic infectionsR56HL142857 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI BROWN, SAMUEL PAUL · 2018 to 2018
$501k
NHLBI NIH HHS R56 HL142857NIAID NIH HHS R01 AI153116NIGMS NIH HHS R01 GM116547
6 · The paper itself

Abstract

Bacteria are highly interactive and possess an extraordinary repertoire of intercellular communication and social behaviors, including quorum sensing (QS). QS has been studied in detail at the molecular level, so mechanistic details are well understood in many species and are often involved in virulence. The use of different animal host models has demonstrated QS-dependent control of virulence determinants and virulence in several human pathogenic bacteria. QS also controls virulence in several plant pathogenic species. Despite the role QS plays in virulence during animal and plant laboratory-engineered infections, QS mutants are frequently isolated from natural infections, demonstrating that the function of QS during infection and its role in pathogenesis remain poorly understood and are fruitful areas for future research. We discuss the role of QS during infection in various organisms and highlight approaches to better understand QS during human infection. This is an important consideration in an era of growing antimicrobial resistance, when we are looking for new ways to target bacterial infections.

Indexed as

Signal TransductionAnimalsBacteriaBacterial InfectionsBacterial ProteinsDisease Models, AnimalGene Expression Regulation, BacterialQuorum SensingVirulenceVirulence FactorsBacterial ProteinsVirulence Factorscell–cell signalingpathogenquorum sensingvirulence

Identifiers

PMID32660382
PMCPMC13064819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.