ArticleCirculation. Cardiovascular imaging2020
Association of Body Mass Index With Coronary Artery Calcium and Subsequent Cardiovascular Mortality: The Coronary Artery Calcium Consortium.
Article in Circulation. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 105 citations in OpenAlex.
- Association between body composition and its longitudinal changes with the progression of coronary artery calcification in hemodialysis patients.BMC nephrology · 2026Observational
- Application of 80 kVp combined with deep learning reconstruction algorithm in overweight patients coronary CT angiography: reduced radiation dose and contrast agent dose.Frontiers in radiology · 2026Article
- Association of serum uric acid with incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Inflammation Mediates the Relationship Between Serum Uric Acid and New-Onset Diabetes Risk in Patients with Coronary Heart Disease: Results from a Multicenter Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association between coronary artery calcification and cardiometabolic, hepatic, and renal markers in a Chinese population undergoing health examinations.American journal of cardiovascular disease · 2026Article
- Artificial Intelligence Chest X-Ray Opportunistic Screening Model for Coronary Artery Calcium Deposition: A Multi-Objective Model With Multimodal Data Fusion.Mayo Clinic proceedings. Digital health · 2025Article
- Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study.European heart journal. Cardiovascular Imaging · 2025Article
- An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults.Acta odontologica Scandinavica · 2025Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- Coronary artery calcifications are not associated with epicardial adipose tissue volume and attenuation on computed tomography in 1,945 individuals with various degrees of glucose disorders.International journal of cardiology. Heart & vasculature · 2025Article
- The Impact of the hsCRP/BMI Ratio on Cardiovascular Outcomes in CAD Patients: A Population-Based Study.Mediators of inflammation · 2025Article
- Exploring the Relationship Between Visceral Fat and Coronary Artery Calcification Risk Using Metabolic Score for Visceral Fat (METS-VF).Life (Basel, Switzerland) · 2024Article
- The value of coronary calcium score in predicting clinical outcomes in patients with chronic coronary syndrome.BMC cardiovascular disorders · 2024Article
- Association of Anthropometric Indices With Midlife Cardiovascular Risk in Young Individuals Without Obesity and Traditional Risk Factors.Journal of the American Heart Association · 2024Article
- Exploring the mediating role of calcium homeostasis in the association between diabetes mellitus, glycemic traits, and vascular and valvular calcifications: a comprehensive Mendelian randomization analysis.Diabetology & metabolic syndrome · 2024Article
- Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study.American journal of preventive cardiology · 2024Article
- Associations between Life's Essential 8 and abdominal aortic calcification among US Adults: a cross-sectional study.BMC public health · 2024Article
- The association of TNF-alpha secretion and mtDNA copy number in CD14Frontiers in molecular biosciences · 2024Article
- The role of coffee and potential mediators in subclinical atherosclerosis: insights from Mendelian randomization study.Frontiers in nutrition · 2024Article
- The Associations Between Abdominal Obesity and Coronary Artery Calcification in Chronic Kidney Disease Population.International journal of nephrology and renovascular disease · 2024Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundObesity is associated with higher risk for coronary artery calcium (CAC), but the relationship between body mass index (BMI) and mortality is complex and frequently paradoxical.
methodsWe analyzed BMI, CAC, and subsequent mortality using data from the CAC Consortium, a multi-centered cohort of individuals free of established cardiovascular disease (CVD) who underwent CAC testing. Mortality was assessed through linkage to the Social Security Death Index and cause of death from the National Death Index. Multivariable logistic regression was used to determine odds ratios for the association of clinically relevant BMI categories and prevalent CAC. Cox proportional hazards regression modeling was used to determine hazard ratios for coronary heart disease, CVD, and all-cause mortality according to categories of BMI and CAC.
resultsOur sample included 36 509 individuals, mean age 54.1 (10.3) years, 34.4% female, median BMI 26.6 (interquartile range, 24.1-30.1), 46.6% had zero CAC, and 10.5% had CAC ≥400. Compared with individuals with normal BMI, the multivariable adjusted odds of CAC >0 were increased in those overweight (odds ratio, 1.13 [95% CI, 1.1-1.2]) and obese (odds ratio, 1.5 [95% CI, 1.4-1.6]). Over a median follow-up of 11.4 years, there were 1550 deaths (4.3%). Compared with normal BMI, obese individuals had a higher risk of coronary heart disease, CVD, and all-cause mortality while overweight individuals, despite a higher odds of CAC, showed no significant increase in mortality. In a sex-stratified analysis, the increase in coronary heart disease, CVD, and all-cause mortality in obese individuals appeared largely limited to men, and there was a lower risk of all-cause mortality in overweight women (hazard ratio, 0.79 [95% CI, 0.63-0.98]).
conclusionsIn a large sample undergoing CAC scoring, obesity was associated with a higher risk of CAC and subsequent coronary heart disease, CVD, and all-cause mortality. However, overweight individuals did not have a higher risk of mortality despite a higher risk for CAC.
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