ArticleCells2020
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review.
Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic Effects of Static Stretching Exercises on Skeletal Muscle Hypertrophy in Healthy Individuals: A Systematic Review and Multilevel Meta-Analysis.Sports medicine - open · 2024Pooled it
- Partial Range, Full Gains? The Effect of 8 Weeks of Partial Range of Motion Training at Long Muscle Lengths on Elbow Flexor Hypertrophy and Strength in Trained Individuals.European journal of sport science · 2025Trial
- Comparison Between Shoulder Flexed and Extended Positions in Elbow Flexion Resistance Training on Regional Hypertrophy and Maximum Strength: Preacher versus Bayesian Cable Curls.European journal of sport science · 2025Trial
- Post-translational modification-regulating biomaterials for regeneration.Bioactive materials · 2026Review
- Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats.Physiological reports · 2026Article
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations.bioRxiv : the preprint server for biology · 2026Article
- Research into resistance training response heterogeneity: a summary of the 2025 conference at the University of Jyväskylä.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Review
- Mechanical Loading Induces the Radial Growth of Myofibrils and Myofibrillogenesis via an mTORC1-Dependent Mechanism.bioRxiv : the preprint server for biology · 2026Article
- Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism.Science advances · 2026Article
- Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors.Reviews in endocrine & metabolic disorders · 2026Review
- Neuromuscular and Functional Adaptations Promoted by Lower Limb Isometric Training with NMES Conditioning Contractions in Older Adults.International journal of environmental research and public health · 2026Article
- Does Performing Partial Repetitions Beyond Momentary Failure Enhance Muscle Hypertrophy in Volume-Load-Equated Calf-Raise Resistance Training?International journal of exercise science · 2026Article
- Does longer-muscle length resistance training cause greater longitudinal growth in humans? A systematic review.Sports medicine and health science · 2026Review
- Tendon-muscle-nerve disconnection in chronic large and massive posterosuperior rotator cuff tears: a targeted narrative mechanistic review and hypothesis-generating framework.Frontiers in cell and developmental biology · 2026Review
- Compression bioreactor for cultured meat.Current research in food science · 2026Article
- Systematic Exploration of Molecular Mechanisms and Natural Herbal Therapeutic Strategies for Cancer Cachexia.Cancers · 2025Review
- Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle.Skeletal muscle · 2025Article
- Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions.Journal of sport and health science · 2025Review
- Blood Flow Restriction Training Prior to and After Anterior Cruciate Ligament Reconstruction: A Scoping Review.Journal of functional morphology and kinesiology · 2025Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding of the macroscopic and microscopic changes that occur when the mechanical environment is altered. For instance, an increase in mechanical loading induces a growth response that is mediated, at least in part, by an increase in the cross-sectional area of the myofibers (i.e., myofiber hypertrophy). However, very little is known about the ultrastructural adaptations that drive this response. Even the most basic questions, such as whether mechanical load-induced myofiber hypertrophy is mediated by an increase in the size of the pre-existing myofibrils and/or an increase in the number myofibrils, have not been resolved. In this review, we thoroughly summarize what is currently known about the macroscopic, microscopic and ultrastructural changes that drive mechanical load-induced growth and highlight the critical gaps in knowledge that need to be filled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.