Broadband Electrical Sensing of a Live Biological Cell with In Situ Single-Connection Calibration.

Xiao Ma, Xiaotian Du, Lei Li, Caroline Ladegard, Xuanhong Cheng, James C M Hwang

Abstract readLetter

In one paragraph

Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Biosensor with Microchannel for Broadband Dielectric Characterization of Nanoliter Cell Suspensions up to 110 GHz.Biosensors · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao MaElectrical and Computer Engineering, Lehigh University, Bethlehem, PA 18015, USA.

Xiaotian DuElectrical and Computer Engineering, Lehigh University, Bethlehem, PA 18015, USA.

Lei LiElectrical and Computer Engineering, Cornell University, New York, NY 14850, USA.

Caroline LadegardBioengineering, Lehigh University, Bethlehem, PA 18015, USA.

Xuanhong ChengBioengineering, Lehigh University, Bethlehem, PA 18015, USA.ORCID 0000-0002-6331-8572

James C M HwangMaterials Science and Engineering, Cornell University, New York, NY 14850, USA.

Funding

Air Force Office of Scientific Research FA9550-16-1-0475Army Research Office W911NF-14-1-0665Division of Electrical, Communications and Cyber Systems 1809623

6 · The paper itself

Abstract

Single-connection in situ calibration using biocompatible solutions is demonstrated in single-cell sensing from 0.5 to 9 GHz. The sensing is based on quickly trapping and releasing a live cell by dielectrophoresis on a coplanar transmission line with a little protrusion in one of its ground electrodes. The same transmission line is used as the calibration standard when covered by various solutions of known permittivities. The results show that the calibration technique may be precise enough to differentiate cells of different nucleus sizes, despite the measured difference being less than 0.01 dB in the deembedded scattering parameters. With better accuracy and throughput, the calibration technique may allow broadband electrical sensing of live cells in a high-throughput cytometer.

Indexed as

ElectricityElectrophoresisCalibrationElectrodesHumansJurkat CellsSingle-Cell Analysisbiological cellsbiosensorscalibrationmicrowave measurementscattering parameters

Identifiers

PMID32660152

DOI10.3390/s20143844

PMCPMC7412152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.