Evidence map›Paper›PMID 32660058›Full record

ArticleMolecules (Basel, Switzerland)2020

Phytochemical Analysis and Trypanocidal Activity of

Claudio Frezza, Alessandro Venditti, Armandodoriano Bianco, Mauro Serafini, Massimo Pitorri, Fabio Sciubba, Maria Enrica Di Cocco, Eleonora Spinozzi, Loredana Cappellacci, Anders Hofer and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Anti-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Claudio FrezzaDepartment of Environmental Biology, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-2968-5264
Alessandro VendittiDepartment of Chemistry, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-1492-6739
Armandodoriano BiancoDepartment of Chemistry, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8622-5742
Mauro SerafiniDepartment of Environmental Biology, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Massimo PitorriDepartment of Chemistry, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Fabio SciubbaDepartment of Chemistry, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Maria Enrica Di CoccoDepartment of Chemistry, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Eleonora SpinozziSchool of Pharmacy, University of Camerino, via Sant'Agostino 1, 62032 Camerino, Italy.
Loredana CappellacciSchool of Pharmacy, University of Camerino, via Sant'Agostino 1, 62032 Camerino, Italy.ORCID 0000-0001-8155-7211
Anders HoferDepartment of Medical Biochemistry and Biophysics, Umeå University, 90736 Umeå, Sweden.
Filippo MaggiSchool of Pharmacy, University of Camerino, via Sant'Agostino 1, 62032 Camerino, Italy.ORCID 0000-0003-1375-4744
Riccardo PetrelliSchool of Pharmacy, University of Camerino, via Sant'Agostino 1, 62032 Camerino, Italy.ORCID 0000-0002-4760-1204
Sapienza University of Rome · ITUniversità di Camerino · ITUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rationale inspiring the discovery of lead compounds for the treatment of human parasitic protozoan diseases from natural sources is the well-established use of medicinal plants in various systems of traditional medicine. On this basis, we decided to select an overlooked medicinal plant growing in central Italy,

Indexed as

Trypanocidal Agents3T3 CellsAnimalsHumansMarrubiumMicePlant ExtractsTrypanosoma brucei bruceiPlant ExtractsTrypanocidal AgentsantiprotozoalHuman African Trypanosomiasis (HAT)Marrubium incanum Desr.salvigeninsecondary metabolites

Identifiers

PMID32660058
PMCPMC7397158
OpenAlexW3041256213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.