ReviewPharmacology, biochemistry, and behavior2020
Differential impact of stress and environmental enrichment on corticolimbic circuits.
Review in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 73 citations in OpenAlex.
- Enriched neighborhood environments relate to episodic memory through prefrontal rather than medial temporal pathways during late childhood and early adolescence.Brain and environment · 2026Article
- Environmental enrichment applied during epileptogenesis increases seizure latency and reduces serum interleukin-6 in a PTZ kindling model.Journal of molecular neuroscience : MN · 2026Article
- Pre-treatment with royal jelly, environmental enrichment, and their combination role in stress induced neurobehavioral deficits in male rats.IBRO neuroscience reports · 2026Article
- Environmental enrichment reverses ELS-induced visceral pain and depression through a prefrontal-limbic circuit involving CB1Rs.Communications biology · 2026Article
- Does Enriched Environment Improve Chronic Immobilization Stress-Induced Cognitive and Behavioral Changes in Adult Male Rats?Cellular and molecular neurobiology · 2026Article
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Prefrontal working memory activity partially mediates link between enriched neighborhood environments and episodic memory among 9-13-year-olds.bioRxiv : the preprint server for biology · 2026Article
- Shelved cages impact affective behavior in Sprague Dawley rats - implications for animal welfare.Laboratory animals · 2026Article
- Environmental enrichment as a mitochondria-targeting systems strategy across neurodegenerative diseases and retinal dystrophies.Frontiers in neuroscience · 2026Review
- Short-term environmental enrichment modulates brain region-specific redox responses in adolescent female mice.Frontiers in aging neuroscience · 2026Article
- Influence of environmental enrichment on rodents' brains: neurochemical and neuroanatomical aspects.Frontiers in veterinary science · 2026Review
- Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome.The Journal of comparative neurology · 2025Article
- Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats.Physiology & behavior · 2025Article
- Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes.Animal microbiome · 2025Article
- Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy.Clinical epigenetics · 2025Review
- Environmental Enrichment and Metformin Combination Improves Cognitive Function through BDNF and HPA Axis in Chronically Stressed Rats.Current Alzheimer research · 2025Article
- Environmental enrichment for neuropathic pain via modulation of neuroinflammation.Frontiers in molecular neuroscience · 2025Review
- Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice.Frontiers in physiology · 2025Article
- Developmental functions of microglia: Impact of psychosocial and physiological early life stress.Neuropharmacology · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Stress exposure can produce profound changes in physiology and behavior that can impair health and well-being. Of note, stress exposure is linked to anxiety disorders and depression in humans. The widespread impact of these disorders warrants investigation into treatments to mitigate the harmful effects of stress. Pharmacological treatments fail to help many with these disorders, so recent work has focused on non-pharmacological alternatives. One of the most promising of these alternatives is environmental enrichment (EE). In rodents, EE includes social, physical, and cognitive stimulation for the animal, in the form of larger cages, running wheels, and toys. EE successfully reduces the maladaptive effects of various stressors, both as treatment and prophylaxis. While we know that EE can have beneficial effects under stress conditions, the morphological and molecular mechanisms underlying these behavioral effects are still not well understood. EE is known to alter neurogenesis, dendrite development, and expression of neurotrophic growth factors, effects that vary by type of enrichment, age, and sex. To add to this complexity, EE has differential effects in different brain regions. Understanding how EE exerts its protective effects on morphological and molecular levels could hold the key to developing more targeted pharmacological treatments. In this review, we summarize the literature on the morphological and molecular consequences of EE and stress in key emotional regulatory pathways in the brain, the hippocampus, prefrontal cortex, and amygdala. The similarities and differences among these regions provide some insight into stress-EE interaction that may be exploited in future efforts toward prevention of, and intervention in, stress-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.