Evidence map›Paper›PMID 32659240›Full record

ArticleJournal of virological methods2020

Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay.

Daniel Goldenberger, Karoline Leuzinger, Kirstine K Sogaard, Rainer Gosert, Tim Roloff, Klaudia Naegele, Aline Cuénod, Alfredo Mari, Helena Seth-Smith, Katharina Rentsch and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virological methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel GoldenbergerClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Karoline LeuzingerClinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Kirstine K SogaardClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.
Rainer GosertClinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Tim RoloffClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.
Klaudia NaegeleClinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Aline CuénodApplied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.
Alfredo MariApplied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.
Helena Seth-SmithClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.
Katharina RentschLaboratory Medicine, University Hospital Basel, Basel, Switzerland.
Vladimira HinićClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Hans H HirschClinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland; Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Transplantation & Clinical Virology, Department Biomedicine, University of Basel, Basel, Switzerland.
Adrian EgliClinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland. Electronic address: adrian.egli@usb.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.

Indexed as

BetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingDiagnostic Tests, RoutineHumansNasopharynxPandemicsPneumonia, ViralPolymerase Chain ReactionReproducibility of ResultsSARS-CoV-2Sensitivity and SpecificityCOBAS 6800COVID-19DiagnosticsGeneXpertNATPCRRespiratory infectionSARS-CoV-2Viruses

Identifiers

PMID32659240
PMCPMC7351036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.