Trial reportChest2020
Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.
Trial report in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Post-hoc mediation analysis of two biomarkers, and survival in acute respiratory distress syndrome.Scientific reports · 2025Trial
- Lung ultrasound aeration score in pediatric ARDS: associations with oxygenation impairment and RALE score.European journal of pediatrics · 2026Observational
- Improving inter-rater reliability in radiographic edema scoring in acute respiratory failure through structured training and expert feedback.ATS scholar · 2026Article
- Quantifying diffuse airspace disease on portable chest radiographs in acute respiratory failure using the RALE score.Intensive care medicine experimental · 2026Article
- Measuring and managing pulmonary edema in ARDS: a narrative review.Critical care (London, England) · 2026Review
- [Cardiac resuscitation-associated lung edema (CRALE): evaluation of diagnostic and therapeutic approaches by an expert group of the German Cardiac Society].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Redefining Acute Respiratory Distress Syndrome: A New Clinical Perspective.Tuberculosis and respiratory diseases · 2026Article
- Assessment of a Grad-CAM interpretable deep learning model for HAPE diagnosis: performance and pitfalls in severity stratification from chest radiographs.BMC medical informatics and decision making · 2025Article
- Clinical Phenotyping in Acute Respiratory Distress Syndrome: Steps Towards Personalized Medicine.Journal of clinical medicine · 2025Article
- Improvement in radiologic findings over time is associated with increased survival in patients with viral ARDS requiring extracorporeal membrane oxygenation.Lung India : official organ of Indian Chest Society · 2025Article
- Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants.Frontiers in pediatrics · 2025Article
- Study on the Predictive Value of a Pulmonary Edema Imaging Score for Delayed Extubation in Patients after Heart Valve Surgery on Cardiopulmonary Bypass.Reviews in cardiovascular medicine · 2024Article
- Glucocorticoid therapy for acute respiratory distress syndrome: Current concepts.Journal of intensive medicine · 2024Review
- Associations of early changes in lung ultrasound aeration scores and mortality in invasively ventilated patients: a post hoc analysis.Respiratory research · 2024Observational
- The chest X-ray score baseline in predicting continuous oxygen therapy failure in low-risk aged patients after thoracic surgery.Journal of thoracic disease · 2024Article
- ARDS Mortality Prediction Model Using Evolving Clinical Data and Chest Radiograph Analysis.Biomedicines · 2024Article
- A New Global Definition of Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2024Article
- Trajectories of Host-Response Subphenotypes in Patients With COVID-19 Across the Spectrum of Respiratory Support.CHEST critical care · 2023Article
- Association of Late Radiographic Assessment of Lung Edema Score with Clinical Outcome in Patients with Influenza-Associated Acute Respiratory Distress Syndrome.Diagnostics (Basel, Switzerland) · 2023Article
- Delayed lung injury on the nonsurgical side increases mortality in patients after lung cancer surgery: a retrospective cohort study.Journal of thoracic disease · 2023Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe Radiographic Assessment of Lung Edema (RALE) score is associated with the severity of ARDS, and treatments targeted at reducing pulmonary edema such as conservative fluid management cause a reduction in RALE score over time. RESEARCH QUESTION: Are early changes in RALE score over time associated with survival in patients with ARDS? STUDY DESIGN AND
methodsData from patients enrolled in three centers in the Lung Imaging for Ventilation sEtting in ARDS (LIVE) trial with available chest radiographs at baseline (day 0) and days 2 or 3 were used. The RALE was scored by two independent reviewers. The primary end point was death by day 90, considering RALE score both at baseline and as a time-varying covariate in a marginal Cox survival model.
resultsRALE was scored from 135, 64, and 88 radiographs on days 0, 2, and 3, respectively. Both baseline RALE (hazard ratio [HR] for each one-point increment, 1.04; 95% CI, 1.01-1.08; P = .006) and the change in RALE over time (HR for each one-point decrease per unit of time, 0.99; 95% CI, 0.99-0.99; P = .03) were associated with death by day 90, even after adjustment for age, sex, BMI, Simplified Acute Physiology Score II, vasopressor use, and total volume of fluids received since study entry.
interpretationThe change in RALE during the first days after ARDS onset is independently associated with survival and may be useful as a surrogate end point in future clinical trials of new therapeutics in ARDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.