Evidence map›Paper›PMID 32659074›Full record

ArticleACS applied materials & interfaces2020

Three-Dimensional Electrodeposition of Calcium Phosphates on Porous Nanofibrous Scaffolds and Their Controlled Release of Calcium for Bone Regeneration.

Xue Mi, Melanie J Gupte, Zhanpeng Zhang, W Benton Swanson, Laurie K McCauley, Peter X Ma

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Biomedical Implants with Charge-Transfer Monitoring and Regulating Abilities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xue MiDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Melanie J GupteDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
Zhanpeng ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
W Benton SwansonDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Laurie K McCauleyDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Peter X MaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID http://orcid.org/0000-0002-0191-9487
University of Michigan · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
Periodontal Engineering Using Biomimetic Nano ScaffoldsR01DE015384 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2011
$2.9M
Regenerating cranial suture (Jaylynn Jones)R01DE027662 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HATCH, NAN E, MISHINA, YUJI · 2018 to 2022
$2.6M
Exosome-mediated Craniofacial Bone Tissue Engineering by Controlled ReleaseF30DE029359 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, WILLIAM BENTON · 2020 to 2024
$231k
NIDCR NIH HHS F30 DE029359NIDCR NIH HHS R01 DE015384NIDCR NIH HHS R01 DE022327NIDCR NIH HHS R01 DE027662NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

To mimic the bone matrix of mineralized collagen and to impart microporous structure to facilitate cell migration and bone regeneration, we developed a nanofibrous (NF) polymer scaffold with highly interconnected pores and three-dimensional calcium phosphate coating utilizing an electrodeposition technique. The mineral content, morphology, crystal structure, and chemical composition could be tailored by adjusting the deposition temperature, voltage, and duration. A higher voltage and a higher temperature led to a greater rate of mineralization. Furthermore, nearly linear calcium releasing kinetics was achieved from the mineralized 3D scaffolds. The releasing rate was controlled by varying the initial electrodeposition conditions. A higher deposition voltage and temperature led to slower calcium release, which was associated with the highly crystalline and stoichiometric hydroxyapatite content. This premineralized NF scaffold enhanced bone regeneration over the control scaffold in a subcutaneous implantation model, which was associated with released calcium ions in facilitating osteogenic cell proliferation.

Indexed as

Bone RegenerationElectroplatingAnimalsBiocompatible MaterialsCalciumCalcium PhosphatesCells, CulturedMaleMiceMice, NudeParticle SizePorosityRabbitsSurface PropertiesBiocompatible MaterialsCalciumCalcium Phosphatesbone regenerationcalcium phosphatenanofibrousproliferationthree-dimensional

Identifiers

PMID32659074
PMCPMC7384879
OpenAlexW3041084462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.