Evidence map›Paper›PMID 32658866›Full record

SynthesisAging2020

Genetic association of hypoxia inducible factor 1-alpha (

Huan Ren, Jian-Quan Luo, Yong-Chao Gao, Man-Yun Chen, Xiao-Ping Chen, Hong-Hao Zhou, Ying Jiang, Wei Zhang

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Protective association of theFrontiers in medicine · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Sestrin2 in hypoxia and hypoxia-related diseases.Redox report : communications in free radical research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Huan RenDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Jian-Quan LuoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
Yong-Chao GaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Man-Yun ChenDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Xiao-Ping ChenDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Hong-Hao ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Ying JiangDepartment of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, P.R. China.
Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.
Central South University · CNXiangya Hospital Central South University · CNNational Clinical Research Center for Digestive Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is an age-related chronic disease associated with a number of complications, emerging as one of the major causes of morbidity and mortality worldwide. Several studies indicated that hypoxia-inducible factor 1-alpha

Indexed as

Diabetes ComplicationsAdolescentAdultAgedFemaleGenetic Predisposition to DiseaseHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedPolymorphism, Single NucleotideRisk AssessmentYoung AdultHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunitdiabetesdiabetic complicationsHIF1ApolymorphismPro582Ser

Identifiers

PMID32658866
PMCPMC7377833
OpenAlexW3042352036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.