Evidence map›Paper›PMID 32658359›Full record

ReviewAllergy2021

SARS-CoV-2, COVID-19, skin and immunology - What do we know so far?

Natalijia Novak, Wenming Peng, Mirjam C Naegeli, Christina Galvan, Isabel Kolm-Djamei, Charlotte Brüggen, Beatriz Cabanillas, Peter Schmid-Grendelmeier, Alba Catala

Open access · hybridAbstract readReview
In one paragraph

Review in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Skin as a Potential Entry Point for SARS-CoV-2 Virus.International journal of molecular sciences · 2026
    Article
  6. SKIN AS A POTENTIAL ENTRY POINT FOR SARS-COV-2.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
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  11. Article
  12. Article
  13. Review
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  15. Review
  16. Review
  17. Article
  18. Adamalysins in COVID-19 - Potential mechanisms behind exacerbating the disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Natalijia NovakDepartment of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany.ORCID 0000-0001-8146-8673
Wenming PengDepartment of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany.
Mirjam C NaegeliDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Christina GalvanDepartment of Dermatology and Venereology, Móstoles Hospital, Madrid, Spain.
Isabel Kolm-DjameiDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Charlotte BrüggenDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Beatriz CabanillasDepartment of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany.
Peter Schmid-GrendelmeierDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-3215-3370
Alba CatalaDepartment of Dermatology and Venereology, Plató Hospital, Barcelona, Spain.
University of Zurich · CHUniversity Hospital Bonn · DEHospital Plató · ESHospital Universitario de Móstoles · ES

Funding

Deutsche Forschungsgemeinschaft 390873048Deutsche Forschungsgemeinschaft EXC2151
6 · The paper itself

Abstract

The pandemic condition coronavirus disease (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can take asymptomatic, mild, moderate, and severe courses. COVID-19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS-CoV-2-positive patients as such features outside the respiratory sphere, are rapidly emerging. Vesicular, urticarial, and maculopapular eruptions and livedo, necrosis, and other vasculitis forms have been reported most frequently in association with SARS-CoV-2 infection. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID-19 patients, discuss potential causative factors, and describe differential diagnostic evaluations. Moreover, we summarize current knowledge about immunologic, clinical, and histologic features of virus- and drug-induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS-CoV-2.

Indexed as

SARS-CoV-2Angiotensin-Converting Enzyme 2COVID-19FemaleHumansMaleSkinSkin DiseasesACE2 protein, humanAngiotensin-Converting Enzyme 2allergydrug hypersensitivityskinvirus

Identifiers

PMID32658359
PMCPMC7404682
OpenAlexW3040844035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.