Evidence map›Paper›PMID 32658180›Full record

ArticleJournal of visualized experiments : JoVE2020

In vivo Mouse Model of Spinal Implant Infection.

Benjamin V Kelley, Christopher Hamad, Stephen D Zoller, Danielle Greig, Zeinab Mamouei, Rene Chun, Kellyn Hori, Nicolas Cevallos, Chad Ishmael, Peter Hsiue and 11 more

Erratum issuedOpen access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A novel rodent model of chronic spinal implant-associated infection.The spine journal : official journal of the North American Spine Society · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Benjamin V KelleyDepartment of Orthopaedic Surgery, University of California Los Angeles.
Christopher HamadDepartment of Orthopaedic Surgery, University of California Los Angeles.
Stephen D ZollerDepartment of Orthopaedic Surgery, University of California Los Angeles.
Danielle GreigDepartment of Orthopaedic Surgery, University of California Los Angeles.
Zeinab MamoueiDepartment of Orthopaedic Surgery, University of California Los Angeles.
Rene ChunDepartment of Orthopaedic Surgery, University of California Los Angeles.
Kellyn HoriDepartment of Orthopaedic Surgery, University of California Los Angeles.
Nicolas CevallosDepartment of Orthopaedic Surgery, University of California Los Angeles.
Chad IshmaelDepartment of Orthopaedic Surgery, University of California Los Angeles.
Peter HsiueDepartment of Orthopaedic Surgery, University of California Los Angeles.
Rishi TrikhaDepartment of Orthopaedic Surgery, University of California Los Angeles.
Troy SekimuraDavid Geffen School of Medicine, University of California Los Angeles.
Brandon GettlemanUniversity of South Carolina School of Medicine, University of South Carolina.
Autreen GolzarDavid Geffen School of Medicine, University of California Los Angeles.
Adrian LinDavid Geffen School of Medicine, University of California Los Angeles.
Thomas OlsonDavid Geffen School of Medicine, University of California Los Angeles.
Ameen ChaudryDavid Geffen School of Medicine, University of California Los Angeles.
Michael M LeDavid Geffen School of Medicine, University of California Los Angeles.
Anthony A ScadutoDepartment of Orthopaedic Surgery, University of California Los Angeles.
Kevin P FrancisDepartment of Orthopaedic Surgery, University of California Los Angeles.
Nicholas M BernthalDepartment of Orthopaedic Surgery, University of California Los Angeles; nbernthal@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteKL2RR033185 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$407k
NCRR NIH HHS KL2 RR033185
6 · The paper itself

Abstract

Spine implant infections portend poor outcomes as diagnosis is challenging and surgical eradication is at odds with mechanical spinal stability. The purpose of this method is to describe a novel mouse model of spinal implant infection (SII) that was created to provide an inexpensive, rapid, and accurate in vivo tool to test potential therapeutics and treatment strategies for spinal implant infections. In this method, we present a model of posterior-approach spinal surgery in which a stainless-steel k-wire is transfixed into the L4 spinous process of 12-week old C57BL/6J wild-type mice and inoculated with 1 x 10

Indexed as

SpineStaphylococcal InfectionsAnimalsDisease Models, AnimalMiceMice, Inbred C57BLProstheses and ImplantsProsthesis-Related InfectionsStaphylococcus aureus

Identifiers

PMID32658180
PMCPMC8601786
OpenAlexW3037826724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.