Evidence map›Paper›PMID 32658080›Full record

Observational studyPancreas2020

Diagnostic Value of Serum Amylase Levels Indicating Computed Tomography-Defined Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Prospective Multicenter Observational Study.

Osamu Inatomi, Shigeki Bamba, Yoshitaka Nakai, Kiyonori Kusumoto, Takumi Kawakami, Takahiro Suzuki, Azumi Suzuki, Bunji Endoh, Shinichi Ota, Akitoshi Inoue and 5 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Pancreas, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Osamu InatomiFrom the Division of Gastroenterology, Department of Medicine.
Shigeki BambaDivision of Clinical Nutrition, Shiga University of Medical Science, Otsu.
Yoshitaka NakaiDepartment of Gastroenterology and Hepatology, Kyoto Katsura Hospital.
Kiyonori KusumotoDepartment of Gastroenterology and Hepatology, Kyoto Katsura Hospital.
Takumi KawakamiDepartment of Gastroenterology, Kyoto First Red Cross Hospital.
Takahiro SuzukiDepartment of Gastroenterology, Kyoto First Red Cross Hospital.
Azumi SuzukiDepartment of Gastroenterology, Kyoto Second Red Cross Hospital.
Bunji EndohDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto.
Shinichi OtaDepartment of Radiology, Shiga University of Medical Science, Otsu, Japan.
Akitoshi InoueDepartment of Radiology, Shiga University of Medical Science, Otsu, Japan.
Yoshio ItokawaDepartment of Gastroenterology and Hepatology, Kyoto Katsura Hospital.
Koki ChikugoDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto.
Akira AndohFrom the Division of Gastroenterology, Department of Medicine.
Yoshinori MizumotoDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto.
Kiyohito TanakaDepartment of Gastroenterology, Kyoto Second Red Cross Hospital.
Kyoto Katsura Hospital · JPKyoto Medical Center · JPShiga University of Medical Science · JPKyoto first Red Cross hospital · JPKrankenhaus vom Roten Kreuz · DERed Cross Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePost-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to investigate cutoff serum amylase levels suggesting post-ERCP pancreatitis using computed tomography as the criterion standard.

methodsWe prospectively followed 2078 cases. Computed tomography was performed in patients whose serum amylase levels exceeded the institutional upper limit 12 to 24 hours after ERCP. Two expert radiologists blindly assessed the images and judged the presence or absence of pancreatitis. Correlations between serum amylase levels with pancreatitis were investigated using receiver operating characteristic analysis.

resultsAmylase levels increased in 416 (23.2%) of 1789 cases included, and 350 cases were analyzed using computed tomography. Post-endoscopic retrograde cholangiopancreatography pancreatitis was diagnosed in 12.0% (214/1789). The cutoff amylase levels for judging pancreatitis after 12 to 24 hours was 2.75 times higher than the institutional upper limit, with an area under the curve of 0.77.

conclusionsThe appropriate cutoff serum amylase level for judging post-ERCP pancreatitis at 12 to 24 hours after ERCP was 2.75 times higher than the institutional upper limit. These results may clarify the definition of post-ERCP pancreatitis.

Indexed as

AdultAgedAged, 80 and overAmylasesCholangiopancreatography, Endoscopic RetrogradeFemaleHumansMaleMiddle AgedPancreatitisProspective StudiesROC CurveTime FactorsTomography, X-Ray ComputedAmylases

Identifiers

PMID32658080
OpenAlexW3043290997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.