Evidence map›Paper›PMID 32657351›Full record

ArticleSchizophrenia bulletin2021

Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.

Suzanne N Avery, Kristan Armstrong, Maureen McHugo, Simon Vandekar, Jennifer Urbano Blackford, Neil D Woodward, Stephan Heckers

Open access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Reduced temporal organization of narrative recall in adults with moderate-severe traumatic brain injury.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of Sleep in Formation of Relational Associative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Suzanne N AveryDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Kristan ArmstrongDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Maureen McHugoDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Simon VandekarDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Jennifer Urbano BlackfordDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Neil D WoodwardDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Stephan HeckersDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Vanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Imaging Hippocampal Function in PsychosisR01MH070560 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HECKERS, STEPHAN · 2005 to 2025
$7.2M
NCATS NIH HHS UL1 TR000445NIMH NIH HHS R01 MH070560
6 · The paper itself

Abstract

backgroundRelational memory, the ability to bind information into complex memories, is moderately impaired in early psychosis and severely impaired in chronic schizophrenia, suggesting relational memory may worsen throughout the course of illness.

methodsWe examined relational memory in 66 early psychosis patients and 64 healthy control subjects, with 59 patients and 52 control subjects assessed longitudinally at baseline and 2-year follow-up. Relational memory was assessed with 2 complementary tasks, to test how individuals learn relationships between items (face-scene binding task) and make inferences about trained relationships (associative inference task).

resultsThe early psychosis group showed impaired relational memory in both tasks relative to the healthy control group. The ability to learn relationships between items remained impaired in early psychosis patients, while the ability to make inferences about trained relationships improved, although never reaching the level of healthy control performance. Early psychosis patients who did not progress to schizophrenia at follow-up had better relational memory than patients who did.

conclusionsRelational memory impairments, some of which improve and are less severe in patients who do not progress to schizophrenia, are a target for intervention in early psychosis.

Indexed as

Disease ProgressionAdolescentAdultCognitive DysfunctionFemaleFollow-Up StudiesHumansLearningLongitudinal StudiesMaleMemory DisordersPsychotic DisordersSchizophreniaYoung Adulthippocampuslongitudinalmemoryschizophreniaschizophreniform

Identifiers

PMID32657351
PMCPMC7825006
OpenAlexW3042372712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.