SynthesisJournal of the National Cancer Institute. Monographs2020
Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Rationale and Framework for the Monograph and Overview of Eligible Studies.
Synthesis in Journal of the National Cancer Institute. Monographs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- Evaluation of Confounding and Selection Bias in Epidemiological Studies of Populations Exposed to Low-Dose, High-Energy Photon Radiation.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Multi-center and multi-reader comparison of abdominopelvic non-contrast and contrast-enhanced CT in the postoperative surveillance of gastrointestinal stromal tumors.Quantitative imaging in medicine and surgery · 2026Article
- Comparison of radiation-related cancer risks from the atomic bomb survivors with studies of pediatric medical radiation exposure.Carcinogenesis · 2025Article
- Projected Lifetime Cancer Risks From Current Computed Tomography Imaging.JAMA internal medicine · 2025Observational
- Robotic radiation shielding system reduces radiation-induced DNA damage in operators performing electrophysiological procedures.Scientific reports · 2025Article
- Site-specific cancer mortality after low-level exposure to ionizing radiation: findings from an update of the International Nuclear Workers Study (INWORKS).American journal of epidemiology · 2025Article
- The impact of low-dose gamma radiation on immune modulation in a mouse model of spontaneous mammary gland tumorigenesis.Frontiers in immunology · 2025Article
- Recurrent medical imaging exposures for the care of patients: one way forward.European radiology · 2024Review
- Virtual Pooled Registry-Cancer Linkage System: an improved method for ascertaining cancer diagnoses.Journal of the National Cancer Institute. Monographs · 2024Article
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- A generalisation of the method of regression calibration and comparison with Bayesian and frequentist model averaging methods.Scientific reports · 2024Article
- Article
- COVID-19 and cancer risk arising from ionizing radiation exposure through CT scans: a cross-sectional study.BMC cancer · 2024Article
- Radiation-Related Thyroid Cancer.Endocrine reviews · 2024Review
- A generalisation of the method of regression calibration and comparison with the Bayesian 2-dimensional Monte Carlo method.Research square · 2023Article
- Effects of low-dose ionizing radiation on genomic instability in interventional radiology workers.Scientific reports · 2023Article
- A generalisation of the method of regression calibration.Scientific reports · 2023Article
- A generalisation of the method of regression calibration.Research square · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Whether low-dose ionizing radiation can cause cancer is a critical and long-debated question in radiation protection. Since the Biological Effects of Ionizing Radiation report by the National Academies in 2006, new publications from large, well-powered epidemiological studies of low doses have reported positive dose-response relationships. It has been suggested, however, that biases could explain these findings. We conducted a systematic review of epidemiological studies with mean doses less than 100 mGy published 2006-2017. We required individualized doses and dose-response estimates with confidence intervals. We identified 26 eligible studies (eight environmental, four medical, and 14 occupational), including 91 000 solid cancers and 13 000 leukemias. Mean doses ranged from 0.1 to 82 mGy. The excess relative risk at 100 mGy was positive for 16 of 22 solid cancer studies and 17 of 20 leukemia studies. The aim of this monograph was to systematically review the potential biases in these studies (including dose uncertainty, confounding, and outcome misclassification) and to assess whether the subset of minimally biased studies provides evidence for cancer risks from low-dose radiation. Here, we describe the framework for the systematic bias review and provide an overview of the eligible studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.