ReviewJournal of the National Cancer Institute. Monographs2020
Issues in Interpreting Epidemiologic Studies of Populations Exposed to Low-Dose, High-Energy Photon Radiation.
Review in Journal of the National Cancer Institute. Monographs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- Evaluation of Confounding and Selection Bias in Epidemiological Studies of Populations Exposed to Low-Dose, High-Energy Photon Radiation.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Rationale and Framework for the Monograph and Overview of Eligible Studies.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Causes of cardiovascular and noncardiovascular death in the ISCHEMIA trial.American heart journal · 2022Trial
- The impact of different strategies for modeling associations between medications at low doses and health outcomes: a simulation study and practical application to postpartum opioid use.American journal of epidemiology · 2025Article
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- A generalisation of the method of regression calibration and comparison with Bayesian and frequentist model averaging methods.Scientific reports · 2024Article
- Article
- Radiation-Related Thyroid Cancer.Endocrine reviews · 2024Review
- A generalisation of the method of regression calibration and comparison with the Bayesian 2-dimensional Monte Carlo method.Research square · 2023Article
- A generalisation of the method of regression calibration.Scientific reports · 2023Article
- A generalisation of the method of regression calibration.Research square · 2023Article
- Circulatory disease mortality among male medical radiation workers in South Korea, 1996-2019.Scandinavian journal of work, environment & health · 2023Article
- Cancer risks among studies of medical diagnostic radiation exposure in early life without quantitative estimates of dose.The Science of the total environment · 2022Review
- Comparison of All Solid Cancer Mortality and Incidence Dose-Response in the Life Span Study of Atomic Bomb Survivors, 1958-2009.Radiation research · 2022Article
- Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses.Environment international · 2022Review
- Impact of Reverse Causation on Estimates of Cancer Risk Associated With Radiation Exposure From Computerized Tomography: A Simulation Study Modeled on Brain Cancer.American journal of epidemiology · 2022Article
- Age effects on radiation response: summary of a recent symposium and future perspectives.International journal of radiation biology · 2022Article
- Epidemiological studies of CT scans and cancer risk: the state of the science.The British journal of radiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article addresses issues relevant to interpreting findings from 26 epidemiologic studies of persons exposed to low-dose radiation. We review the extensive data from both epidemiologic studies of persons exposed at moderate or high doses and from radiobiology that together have firmly established radiation as carcinogenic. We then discuss the use of the linear relative risk model that has been used to describe data from both low- and moderate- or high-dose studies. We consider the effects of dose measurement errors; these can reduce statistical power and lead to underestimation of risks but are very unlikely to bring about a spurious dose response. We estimate statistical power for the low-dose studies under the assumption that true risks of radiation-related cancers are those expected from studies of Japanese atomic bomb survivors. Finally, we discuss the interpretation of confidence intervals and statistical tests and the applicability of the Bradford Hill principles for a causal relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.