ArticleeLife2020
Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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Who cites it
85 citing papers in PubMed.
- Sleep to remember, sleep to protect: increased sleep spindle and theta activity predict fewer intrusive memories after analogue trauma.Translational psychiatry · 2026Trial
- Effects of Olfactory Learning Context Reactivation During Sleep on Training Success in a Double-Blind Randomized Controlled Sensorimotor Rhythm Neurofeedback Protocol: A Pilot Study.Psychophysiology · 2025Trial
- The effect of zolpidem on targeted memory reactivation during sleep.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Trial
- Biological mechanisms of different exercise modalities in improving sleep disorders: A review.IBRO neuroscience reports · 2026Review
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Human brain-wide activation of sleep rhythms.eLife · 2026Article
- Random auditory stimulation during sleep disturbs traveling slow waves and declarative memory.iScience · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.bioRxiv : the preprint server for biology · 2026Article
- Article
- Classifying Sleep Slow Oscillations in Low Density EEG.Neuroinformatics · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- High frequency head impact exposure changes hippocampal sharp-wave ripple architecture.PloS one · 2026Article
- Hippocampal Ripples during Offline Periods Predict Human Motor Sequence Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Stimulating the Stimulated Cortex-Frontocortical Anodal Electric Stimulation Combined With Closed-Loop Acoustic Stimulation During Sleep Impairs Memory in Subjects With High Cognitive Ability.The European journal of neuroscience · 2025Article
- Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Physical activity simultaneously improves working memory and ripple-spindle coupling.Communications biology · 2025Article
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. Mechanistically, this information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. To test this hypothesis, we analyzed intracranial and scalp Electroencephalography sleep recordings from pre-surgical epilepsy patients. We first observed a concurrent spindle power increase in hippocampus (HIPP) and neocortex (NC) time-locked to individual hippocampal ripple events. Coherence analysis confirmed elevated levels of hippocampal-neocortical spindle coupling around ripples, with directionality analyses indicating an influence from NC to HIPP. Importantly, these hippocampal-neocortical dynamics were particularly pronounced during long-duration compared to short-duration ripples. Together, our findings reveal a potential mechanism underlying active consolidation, comprising a neocortical-hippocampal-neocortical reactivation loop initiated by the neocortex. This hippocampal-cortical dialogue is mediated by sleep spindles and is enhanced during long-duration hippocampal ripples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.