Evidence map›Paper›PMID 32657253›Full record

Trial reportEpigenetics

Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.

Nathan Rabinovitch, Meaghan J Jones, Nicole Gladish, Anna V Faino, Matthew Strand, Alexander M Morin, Julie MacIsaac, David T S Lin, Paul R Reynolds, Amrit Singh and 3 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Nathan RabinovitchDepartment of Pediatrics P: 303-398-1992, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
Meaghan J JonesDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.ORCID 0000-0003-1593-997X
Nicole GladishDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
Anna V FainoBiostatistics Program P: 206-667-4995, Public Health Division, Fred Hutchinson Cancer Research Center , Seattle, WA, USA.
Matthew StrandDepartment of Medicine P: 303-398-1862, National Jewish Health , Denver, CO, USA.
Alexander M MorinDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
Julie MacIsaacDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
David T S LinDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.ORCID 0000-0001-5695-9446
Paul R ReynoldsDepartment of Medicine P: 303-398-1862, National Jewish Health , Denver, CO, USA.
Amrit SinghDepartment of Pathology and Laboratory Medicine P: 604-764-5827, University of British Columbia , Vancouver, BC, Canada.
Erwin W GelfandDepartment of Pediatrics P: 303-398-1992, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
Michael S KoborDepartment of Medical Genetics P: 604-875-3194, Center for Molecular Medicine and Therapeutics, University of British Columbia/British Columbia Children's Hospital Research Institute , Vancouver, BC, Canada.
Christopher CarlstenDepartment of Medicine, P: 604-875-4729, University of British Columbia , Vancouver, BC, Canada.
University of British Columbia · CANational Jewish Health · USFred Hutch Cancer Center · US

Funding

CIHR
6 · The paper itself

Abstract

Air pollution is associated with early declines in lung function and increased levels of asthma-related cysteinyl leukotrienes (CysLT) but a biological pathway linking this rapid response has not been delineated. In this randomized controlled diesel exhaust (DE) challenge study of 16 adult asthmatics, increased exposure-attributable urinary leukotriene E4 (uLTE4, a biomarker of cysteinyl leukotriene production) was correlated (p = 0.04) with declines in forced expiratory volume in 1-second (FEV

Indexed as

Air PollutionAsthmaDNA MethylationHumansLeukocytes, MononuclearLungReceptors, G-Protein-CoupledReceptors, LeukotrieneGPR17 protein, humanleukotriene D4 receptorReceptors, G-Protein-CoupledReceptors, LeukotrieneAsthmacysteinyl leukotrienediesel exhaustepigeneticsGPR17methylation

Identifiers

PMID32657253
PMCPMC7889228
OpenAlexW3041603305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.