Evidence map›Paper›PMID 32657158›Full record

ArticleAmerican journal of physiology. Renal physiology2020

A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.

Ryan J Cornelius, Avika Sharma, Xiao-Tong Su, Jin-Jin Guo, Jill A McMahon, David H Ellison, Andrew P McMahon, James A McCormick

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Renal TRPM6 but not Kv1.1 is required for magnesium homeostasis in mice.American journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.American journal of physiology. Renal physiology · 2024
    Article
  10. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  11. Article
  12. mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  13. Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.American journal of physiology. Renal physiology · 2024
    Article
  14. Article
  15. Article
  16. Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (NaHypertension (Dallas, Tex. : 1979) · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ryan J CorneliusDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0002-1389-1493
Avika SharmaDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Xiao-Tong SuDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0001-8121-8105
Jin-Jin GuoDepartment of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
Jill A McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-2915-265X
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Oregon Health & Science University · USUniversity of Southern California · US

Funding

CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEYR01DK054364 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 1998 to 2022
$6.9M
Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
Four-dimensional Modeling of Mouse and Human Nephrogenesis.U01DK110792 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2016 to 2020
$1.9M
Role of the COP9 Signalosome (CSN) in kidney disease and hypertensionK01DK120790 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI CORNELIUS, RYAN J · 2020 to 2024
$650k
Regulation of renal ion transport by the CUL3-WNK-SPAK pathwayR56DK117903 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCCORMICK, JAMES A · 2019 to 2019
$116k
BLRD VA I01 BX002228HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK054196NIDDK NIH HHS K01 DK120790NIDDK NIH HHS R01 DK054364NIDDK NIH HHS R01 DK098141NIDDK NIH HHS R56 DK117903NIDDK NIH HHS U01 DK110792U.S. Department of Veterans Affairs (VA) 1I01BX002228
6 · The paper itself

Abstract

Cre-lox technology has revolutionized research in renal physiology by allowing site-specific genetic recombination in individual nephron segments. The distal convoluted tubule (DCT), consisting of distinct early (DCT1) and late (DCT2) segments, plays a central role in Na

Indexed as

AnimalsEstrogen AntagonistsGene Expression RegulationKidney Tubules, DistalMiceRecombinasesSodium Chloride SymportersSolute Carrier Family 12, Member 3TamoxifenEstrogen AntagonistsRecombinasesSlc12a3 protein, mouseSodium Chloride SymportersSolute Carrier Family 12, Member 3TamoxifenCre recombinasedistal convoluted tubuleNaCl cotransporterpotassiumsodium

Identifiers

PMID32657158
PMCPMC7509282
OpenAlexW3042931196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.