ArticleJournal of clinical neurology (Seoul, Korea)2020
Alterations in Structural and Functional Connectivities in Patients with End-Stage Renal Disease.
Article in Journal of clinical neurology (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- The Kidney-Brain Axis in Chronic Kidney Disease: Uremic Toxins, Cognitive Decline, Mechanistic Pathways, Biomarkers and Therapeutic Perspectives.Biomedicines · 2026Review
- Refractory Status Epilepticus as an Initial Manifestation of IgA Nephropathy.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease.Frontiers in psychiatry · 2026Article
- Biological organ ages associate with risk of chronic diseases in a community-based population.JCI insight · 2025Article
- Cognitive impairment in chronic kidney disease: mechanisms, clinical manifestations, and management strategies.Metabolic brain disease · 2025Review
- Investigating Brain Functional Connectivity and Its Correlation With Cognitive Dysfunction in Chronic Kidney Disease Patients via Resting-State fMRI.Brain and behavior · 2025Article
- Article
- Multilayer network analysis in patients with end-stage kidney disease.Scientific reports · 2024Article
- Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease.Kidney research and clinical practice · 2024Article
- Persistent proteinuria is associated with the occurrence of cardiovascular disease: a nationwide population-based cohort study.Scientific reports · 2024Article
- Difference in functional connectivity between end-stage renal disease patients with and without restless legs syndrome: A prospective study.Sleep & breathing = Schlaf & Atmung · 2024Article
- The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study.Scientific reports · 2023Article
- Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study.Journal of clinical neurology (Seoul, Korea) · 2023Article
- The effects of hemodialysis on the functional brain connectivity in patients with end-stage renal disease with functional near-infrared spectroscopy.Scientific reports · 2023Article
- Altered Resting-State Functional Networks in Nondialysis Patients with Stage 5 Chronic Kidney Disease: A Graph-Theoretical Analysis.Brain sciences · 2023Article
- Network differences based on arterial spin labeling related to anti-seizure medication response in focal epilepsy.Neuroradiology · 2022Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- K-Means Clustering Algorithm-Based Functional Magnetic Resonance for Evaluation of Regular Hemodialysis on Brain Function of Patients with End-Stage Renal Disease.Computational and mathematical methods in medicine · 2022Article
- Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.Frontiers in neuroscience · 2022Article
- Abnormal brain functional networks in end-stage renal disease patients with cognitive impairment.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeThe aim of this study was to evaluate the structural and functional connectivities of brain network using graph theoretical analysis in neurologically asymptomatic patients with end-stage renal disease (ESRD). We further investigated the prevalence of cognitive impairment (CI) in ESRD patients and analyzed the association between network measures of brain connectivity and cognitive function.
methodsWe prospectively enrolled 40 neurologically asymptomatic ESRD patients, 40 healthy controls, and 20 disease controls. All of the subjects underwent diffusion-tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI). We calculated measures of structural and functional connectivities based on DTI and rs-fMRI, respectively, and investigated differences therein between the ESRD patients and the healthy controls. We assessed cognitive function in the ESRD patients using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery.
resultsThe ESRD patients exhibited decreased global structural and functional brain connectivities, as well as alterations of network hubs compared to the healthy controls and disease controls. About 70% of the ESRD patients had CI. Moreover, ESRD patients without CI exhibited decreased global connectivity and alterations of network hubs. Furthermore, there was a significant positive association between measures of brain connectivity and cognitive function.
conclusionsWe found that ESRD patients exhibited decreased structural and functional brain connectivities, and that there was a significant association between brain connectivity and cognitive function. These alterations in the brain network may contribute to the pathophysiological mechanism of CI in ESRD patients.
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