ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06783010 (Sviluppo di Uno Score di Rischio Multidimensionale Basato Sui Deficit Sensoriali, Con un Approccio in Ensemble Learning, Per il Deterioramento Cognitivo in Una Coorte di Anziani Dell'Italia Meridionale), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sviluppo di Uno Score di Rischio Multidimensionale Basato Sui Deficit Sensoriali, Con un Approccio in Ensemble Learning, Per il Deterioramento Cognitivo in Una Coorte di Anziani Dell'Italia Meridionale
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- mHealth Apps for Dementia, Alzheimer Disease, and Other Neurocognitive Disorders: Systematic Search and Environmental Scan.JMIR mHealth and uHealth · 2024Pooled it
- Sensory Impairment and Risk of Elder Mistreatment in Community-Dwelling Older Adults.Journal of the American Geriatrics Society · 2026Article
- Time-to-event risk prediction of dual sensory loss in middle-aged patients with symptomatic knee osteoarthritis: model development, preliminary external validation, and explainability analysis.BMC medical informatics and decision making · 2026Article
- Associations Between Inflammation and Multisensory Impairment Among Older Adults.Journal of the American Geriatrics Society · 2025Article
- Relationship of Multiple Sensory Impairments With Physical Performance in Older Adults in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Subjective hearing loss is not associated with an increased risk of Alzheimer's disease dementia.Heliyon · 2024Article
- Sensory Loss and Risk of Dementia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- A study on cognitive trajectory changes and predictive factors in middle-aged and older adults individuals with dual sensory impairment based on the health social determinants model.Frontiers in public health · 2024Article
- Alterations of Audiovisual Integration in Alzheimer's Disease.Neuroscience bulletin · 2023Review
- Local Brain Network Alterations and Olfactory Impairment in Alzheimer's Disease: An fMRI and Graph-Based Study.Brain sciences · 2023Article
- Population-attributable fractions of risk factors for all-cause dementia in China rural and urban areas: a cross-sectional study.Journal of neurology · 2022Article
- Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults.Neurology · 2022Article
- Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe created a summary score for multiple sensory (multisensory) impairment and evaluated its association with dementia.
methodsWe studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were assessed in regression models adjusting for demographics and health conditions.
resultsDementia risk was 2.05 times higher (95% confidence interval [CI] 1.50-2.81) comparing "poor" to "good" multisensory score tertiles and 1.45 times higher comparing the "middle" to "good" tertiles (95% CI 1.09-1.91). Each point worse in the multisensory function score was associated with faster rates of cognitive decline (P < .05).
conclusionsWorsening multisensory function, even at mild levels, was associated with accelerated cognitive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.