ArticleBrain and behavior2020
Intra and inter: Alterations in functional brain resting-state networks after peripheral nerve injury.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- A case report of thumb weakness misdiagnosed as radial neuroma and resulting in upper limb dysfunction after surgery.Frontiers in rehabilitation sciences · 2026Article
- Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair.Brain and behavior · 2023Article
- Biomimetic chitosan scaffolds with long-term controlled release of nerve growth factor repairs 20-mm-long sciatic nerve defects in rats.Neural regeneration research · 2022Article
- Intra and inter: Alterations in functional brain resting-state networks in patients with functional constipation.Frontiers in neuroscience · 2022Article
- Intra and inter: Alterations in functional brain resting-state networks after peripheral nerve injury.Brain and behavior · 2020Article
- A review of research progress of mirror therapy in peripheral nerve injury.Frontiers in neurologyReview
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9 authors at 1 institution in 1 country.
Funding
Abstract
introductionNumerous treatments suggest that brain plasticity changes after peripheral nerve injury (PNI), and most studies examining functional magnetic resonance imaging focused on abnormal changes in specific brain regions. However, it is the large-scale interaction of neuronal networks instead of isolated brain regions contributed to the functional recovery after PNI. In the present study, we examined the intra- and internetworks alterations between the related functional resting-state networks (RSNs) in a sciatic nerve injury rat model.
methodsNinety-six female rats were divided into a control and model group. Unilateral sciatic nerve transection and direct anastomosis were performed in the latter group. We used an independent component analysis (ICA) algorithm to observe the changes in RSNs and assessed functional connectivity between different networks using the functional networks connectivity (FNC) toolbox.
resultsSix RSNs related to PNI were identified, including the basal ganglia network (BGN), sensorimotor network (SMN), salience network (SN), interoceptive network (IN), cerebellar network (CN), and default mode network (DMN). The model group showed significant changes in whole-brain FC changes within these resting-state networks (RSNs), but four of these RSNs exhibited a conspicuous decrease. The interalterations performed that significantly decreased FNC existed between the BGN and SMN, BGN and IN, and BGN and DMN (p < .05, corrected). A significant increase in FNC existed between DMN and CN and between CN and SN (p < .05, corrected).
conclusionThe results showed the large-scale functional reorganization at the network level after PNI. This evidence reveals new implications to the pathophysiological mechanisms in brain plasticity of PNI.
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