Trial reportObesity (Silver Spring, Md.)2020
A Factorial Experiment to Optimize Remotely Delivered Behavioral Treatment for Obesity: Results of the Opt-IN Study.
Trial report in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624358 (Physical Activity in Adolescents With Chronic Kidney Disease), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
49 citing papers in PubMed, 68 citations in OpenAlex.
- A pilot trial of 'HypoPals': Assessing trial procedures feasibility and intervention acceptability for a prospective digital hypoglycemia behavioral intervention study.Contemporary clinical trials · 2026Trial
- An Adaptive Behavioral Intervention for Weight Loss Management: A Randomized Clinical Trial.JAMA · 2024Trial
- Scalable Telehealth Cancer Care: integrated healthy lifestyle program to live well after cancer treatment.Journal of the National Cancer Institute. Monographs · 2024Trial
- Harnessing technology and gamification to increase adult physical activity: a cluster randomized controlled trial of the Columbia Moves pilot.The international journal of behavioral nutrition and physical activity · 2023Trial
- Evaluation of a combined, online intervention for binge-type eating disorders and high body weight in young adults.Eating behaviors · 2023Trial
- A Hybrid Evaluation-Optimization Trial to Evaluate an Intervention Targeting the Intersection of Alcohol and Sex in College Students and Simultaneously Test an Additional Component Aimed at Preventing Sexual Violence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Trial
- Optimizing an extended care intervention to promote weight loss maintenance: Protocol for the OPT-X multiphase optimization strategy factorial trial.Contemporary clinical trials · 2026Article
- Physical activity partners for women with cardiovascular disease risk: Proof-of-concept trial with daily assessment.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Identifying the most effective components of a physical activity intervention for adults with knee replacement: the MOST Energized! study protocol.BMC musculoskeletal disorders · 2026Article
- Perceived barriers and facilitators to engagement and behavioral enactment in weight management interventions among racial and ethnic minorities.Discover public health · 2026Article
- Impact of an MRI Body Fat Imaging Report on Obesity-Related Cardiometabolic Risk: Findings From the BODY-REAL Study, A Randomized Trial.Obesity science & practice · 2025Article
- Understanding the selection of support partners in a behavioral weight loss program.Psychology & health · 2025Article
- Integrating implementation science and intervention optimization.Implementation science : IS · 2025Article
- Perceived Barriers and Facilitators to Engagement and Behavioral Enactment in Weight Management Interventions Among Racial and Ethnic Minorities.Research square · 2025Article
- The past, present, and future of behavioral obesity treatment.International journal of obesity (2005) · 2025Review
- Results of a pilot sequential multiple assignment randomized trial using counseling to augment a digital weight loss program.Obesity science & practice · 2024Article
- Addressing rural health disparities by optimizing "high-touch" intervention components in digital obesity treatment: The iREACH Rural study.Contemporary clinical trials · 2024Article
- Engagement with Digital Weight Loss Intervention Components and Weight Outcomes.Journal of technology in behavioral science · 2024Article
- Optimization of implementation strategies using the Multiphase Optimization STratgey (MOST) framework: Practical guidance using the factorial design.Translational behavioral medicine · 2024Article
- A posterior expected value approach to decision-making in the multiphase optimization strategy for intervention science.Psychological methods · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveIntensive behavioral obesity treatments face scalability challenges, but evidence is lacking about which treatment components could be cut back without reducing weight loss. The Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity (Opt-IN) study applied the Multiphase Optimization Strategy to develop an entirely remotely delivered, technology-supported weight-loss package to maximize the amount of weight loss attainable for ≤$500.
methodsSix-month weight loss was examined among adults (N = 562) with BMI ≥ 25 who were randomly assigned to conditions in a factorial experiment crossing five dichotomous treatment components set to either low/high (12 vs. 24 coaching calls) or off/on (primary care provider reports, text messaging, meal replacements, and buddy training).
resultsAbout 84.3% of participants completed the final assessment. The treatment package yielding maximum weight loss for ≤$500 included 12 coaching calls, buddy training, and primary care provider progress reports; produced average weight loss of 6.1 kg, with 57.1% losing ≥5% and 51.8% losing ≥7%; and cost $427 per person. The most expensive candidate-treatment component (24 vs. 12 coaching calls) was screened out of the optimized treatment package because it did not increase weight loss.
conclusionsSystematically testing each treatment component's effect on weight loss made it possible to eliminate more expensive but less impactful components, yielding an optimized, resource-efficient obesity treatment for evaluation in a randomized controlled trial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.