Evidence map›Paper›PMID 32656952›Full record

ArticleMolecular nutrition & food research2020

Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila.

Rafael R Segura Munoz, Truyen Quach, João C Gomes-Neto, Yibo Xian, Pamela A Pena, Steven Weier, Michael A Pellizzon, Hatem Kittana, Liz A Cody, Abby L Geis and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Rafael R Segura MunozDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Truyen QuachDepartment of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
João C Gomes-NetoDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Yibo XianDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0002-2468-203X
Pamela A PenaDepartment of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Steven WeierDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Michael A PellizzonResearch Diets, Inc, New Brunswick, NJ, 08901, USA.
Hatem KittanaDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Liz A CodyDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Abby L GeisDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Kari HeckDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Robert J SchmaltzDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Laure B BindelsDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Edgar B CahoonNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Andrew K BensonDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Tom Elmo ClementeNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Amanda E Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0003-0950-7548
University of Nebraska–Lincoln · USRutgers, The State University of New Jersey · US

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
NIGMS NIH HHS P20 GM104320
6 · The paper itself

Abstract

scopePrevious studies have suggested that diets rich in omega-3 and low in omega-6 long-chain polyunsaturated fatty acids (PUFAs) can limit the development of metabolic syndrome (MetS). Transgenic soybeans yielding oils enriched for omega-3 PUFAs represent a new and readily-available option for incorporating omega-3 PUFAs into diets to provide health benefits. METHODS AND

resultsTransgenic soybean oils, enriched for either stearidonic acid (SDA) or eicosapentaenoic acid (EPA), are incorporated into diets to test their effects on limiting the development of MetS in a mouse model of diet-induced obesity. Supplementation with SDA- but not EPA-enriched oils improved features of MetS compared to feeding a control wild-type oil. Because previous studies have linked the gut microorganism Akkermansia muciniphila to the metabolic effects of feeding omega-3 PUFAs, the causal contribution of A. muciniphila to mediating the metabolic benefits provided by SDA-enriched diets is investigated. Although A. muciniphila is not required for SDA-induced metabolic improvements, this microorganism does modulate levels of saturated and mono-unsaturated fatty acids in host adipose tissues.

conclusionTogether, these findings support the utilization of SDA-enriched diets to modulate weight gain, glucose metabolism, and fatty acid profiles of liver and adipose tissue.

Indexed as

Adipose TissueAkkermansiaAnimalsDietary SupplementsDiet, High-FatEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFood, FortifiedGastrointestinal MicrobiomeGlucoseMaleMice, Inbred C57BLObesityPlants, Genetically ModifiedSoybean OilEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedGlucoseSoybean Oilstearidonic acidAkkermansia muciniphilametabolic syndromepolyunsaturated fatty acidssoybean oil

Identifiers

PMID32656952
PMCPMC8606245
OpenAlexW3043629845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.