ReviewReviews in medical virology2020
Lessons from dermatology about inflammatory responses in Covid-19.
Review in Reviews in medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing.Frontiers in immunology · 2023Review
- Cutaneous Manifestations of Coronavirus Disease 2019: Skin Narratives and Dialogues.The Journal of clinical and aesthetic dermatology · 2022Article
- Retrospective View of Four Cases of Cutaneous Manifestations in COVID-19 Patients in an Acute Care Setting.Cureus · 2022Article
- Skin manifestations in patients with COVID-19: a prospective observational study during the first wave of the pandemic in the UK and review of the recent literature.European journal of dermatology : EJD · 2022Observational
- A bird's eye view on the role of dendritic cells in SARS-CoV-2 infection: Perspectives for immune-based vaccines.Allergy · 2022Review
- COVID-19 and Its Repercussions on Oral Health: A Review.Medicina (Kaunas, Lithuania) · 2021Review
- Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2.Nature communications · 2021Article
- Potential Misdiagnosis between COVID-19 and Dengue Infection Using Rapid Serological Test.Infectious disease reports · 2021Article
- Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies.Science advances · 2021Article
- Skin manifestations of COVID-19: A worldwide review.JAAD international · 2021Review
- Covid-19 and dengue: Double punches for dengue-endemic countries in Asia.Reviews in medical virology · 2021Review
- Serological cross-reaction and coinfection of dengue and COVID-19 in Asia: Experience from Indonesia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Projected supportive effects of PycnogenolInternational journal of antimicrobial agents · 2020Review
- Lessons from dermatology about inflammatory responses in Covid-19.Reviews in medical virology · 2020Review
- Clinicopathologic features between different viral epidemic outbreaks involving the skin.Clinics in dermatologyReview
- Commentary: COVID-19 pandemic - 1 Year later.Clinics in dermatologyArticle
- Clinicopathologic features among different viral epidemic outbreaks involving the skin.Clinics in dermatologyArticle
- Virology and Etiopathogenesis of COVID-19 with Special Reference to Cutaneous Implications.Indian journal of dermatologyArticle
- Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns.Clinics in dermatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SARS-Cov-2 is a single-stranded RNA virus composed of 16 non-structural proteins (NSP 1-16) with specific roles in the replication of coronaviruses. NSP3 has the property to block host innate immune response and to promote cytokine expression. NSP5 can inhibit interferon (IFN) signalling and NSP16 prevents MAD5 recognition, depressing the innate immunity. Dendritic cells, monocytes, and macrophages are the first cell lineage against viruses' infections. The IFN type I is the danger signal for the human body during this clinical setting. Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic acids. In Covid-19 the pathogenesis is not yet fully understood, but viral and host factors seem to play a key role. Important points in severe Covid-19 are characterized by an upregulated innate immune response, hypercoagulopathy state, pulmonary tissue damage, neurological and/or gastrointestinal tract involvement, and fatal outcome in severe cases of macrophage activation syndrome, which produce a 'cytokine storm'. These systemic conditions share polymorphous cutaneous lesions where innate immune system is involved in the histopathological findings with acute respiratory distress syndrome, hypercoagulability, hyperferritinemia, increased serum levels of D-dimer, lactic dehydrogenase, reactive-C-protein and serum A amyloid. It is described that several polymorphous cutaneous lesions similar to erythema pernio, urticarial rashes, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicles lesions, and purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema. This review describes the complexity of Covid-19, its pathophysiological and clinical aspects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.