Evidence map›Paper›PMID 32656742›Full record

ArticleInternational journal of clinical oncology2020

Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism.

Ryo Takahashi, Yohei Sato, Momoko Kimishima, Tetsuo Shiohara, Manabu Ohyama

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. PD-1/PD-L1 axis in organ fibrosis.Frontiers in immunology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ryo TakahashiFlow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan.
Yohei SatoDepartment of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan.
Momoko KimishimaDepartment of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan.
Tetsuo ShioharaFlow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan.
Manabu OhyamaFlow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan. manabuohy@ks.kyorin-u.ac.jp.ORCID http://orcid.org/0000-0002-2662-5717
Kyorin University · JP

Funding

Japan Agency for Medical Research and Development JP16ek0410025
6 · The paper itself

Abstract

backgroundThe blockade of cell surface PD-1 (

methodsIntracellular PD-1 expression status in T cell subsets in AMM cases during nivolumab administration was chronologically characterized. The kinetics of PD-1 molecules within AMM-derived T cells was assessed in vitro in conjunction with their functional properties.

resultsIncrease in

conclusionsAccumulated

Indexed as

Antineoplastic Agents, ImmunologicalBiomarkers, TumorHumansImmunotherapyMelanomaNivolumabProgrammed Cell Death 1 ReceptorT-LymphocytesTumor EscapeAntineoplastic Agents, ImmunologicalBiomarkers, TumorNivolumabPDCD1 protein, humanProgrammed Cell Death 1 ReceptorAdvanced malignant melanomaCutaneous immunotherapy-specific immune-related adverse eventsirAEsNivolumabPD-1

Identifiers

PMID32656742
OpenAlexW3042108368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.